FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3009841123> ?p ?o ?g. }

• W3009841123 endingPage "3679" @default.
• W3009841123 startingPage "3666" @default.
• W3009841123 abstract "Abstract Fatty acid synthase (FASN) is commonly overexpressed in prostate cancer and associated with tumour progression. FASN is responsible for de novo synthesis of the fatty acid palmitate; the building block for protein palmitoylation. Recent work has suggested that alongside its established role in promoting cell proliferation FASN may also promote invasion. We now find depletion of FASN expression increases prostate cancer cell adhesiveness, impairs HGF-mediated cell migration and reduces 3D invasion. These changes in motility suggest that FASN can mediate actin cytoskeletal remodelling; a process known to be downstream of Rho family GTPases. Here, we demonstrate that modulation of FASN expression specifically impacts on the palmitoylation of the atypical GTPase RhoU. Impaired RhoU activity in FASN depleted cells leads to reduced adhesion turnover downstream of paxillin serine phosphorylation, which is rescued by addition of exogenous palmitate. Moreover, canonical Cdc42 expression is dependent on the palmitoylation status of RhoU. Thus we uncover a novel relationship between FASN, RhoU and Cdc42 that directly influences cell migration potential. These results provide compelling evidence that FASN activity directly promotes cell migration and supports FASN as a potential therapeutic target in metastatic prostate cancer." @default.
• W3009841123 created "2020-03-13" @default.
• W3009841123 creator A5003951535 @default.
• W3009841123 creator A5005639182 @default.
• W3009841123 creator A5006176965 @default.
• W3009841123 creator A5021275777 @default.
• W3009841123 creator A5021719937 @default.
• W3009841123 creator A5032072845 @default.
• W3009841123 creator A5040491062 @default.
• W3009841123 creator A5047057307 @default.
• W3009841123 creator A5049637651 @default.
• W3009841123 creator A5054103832 @default.
• W3009841123 creator A5071763026 @default.
• W3009841123 creator A5080666019 @default.
• W3009841123 date "2020-03-05" @default.
• W3009841123 modified "2023-10-18" @default.
• W3009841123 title "Lipogenic signalling modulates prostate cancer cell adhesion and migration via modification of Rho GTPases" @default.
• W3009841123 cites W1967515271 @default.
• W3009841123 cites W1974420063 @default.
• W3009841123 cites W1986234170 @default.
• W3009841123 cites W1997143054 @default.
• W3009841123 cites W2002500046 @default.
• W3009841123 cites W2004619403 @default.
• W3009841123 cites W2012034410 @default.
• W3009841123 cites W2032691440 @default.
• W3009841123 cites W2058569850 @default.
• W3009841123 cites W2066651120 @default.
• W3009841123 cites W2069072470 @default.
• W3009841123 cites W2086641174 @default.
• W3009841123 cites W2138110344 @default.
• W3009841123 cites W2140584796 @default.
• W3009841123 cites W2153178365 @default.
• W3009841123 cites W2154409398 @default.
• W3009841123 cites W2194329753 @default.
• W3009841123 cites W2282380036 @default.
• W3009841123 cites W2396960584 @default.
• W3009841123 cites W2560396365 @default.
• W3009841123 cites W2719529748 @default.
• W3009841123 cites W2762782873 @default.
• W3009841123 cites W2775062021 @default.
• W3009841123 cites W2905917937 @default.
• W3009841123 doi "https://doi.org/10.1038/s41388-020-1243-2" @default.
• W3009841123 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7190568" @default.
• W3009841123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32139877" @default.
• W3009841123 hasPublicationYear "2020" @default.
• W3009841123 type Work @default.
• W3009841123 sameAs 3009841123 @default.
• W3009841123 citedByCount "28" @default.
• W3009841123 countsByYear W30098411232020 @default.
• W3009841123 countsByYear W30098411232021 @default.
• W3009841123 countsByYear W30098411232022 @default.
• W3009841123 countsByYear W30098411232023 @default.
• W3009841123 crossrefType "journal-article" @default.
• W3009841123 hasAuthorship W3009841123A5003951535 @default.
• W3009841123 hasAuthorship W3009841123A5005639182 @default.
• W3009841123 hasAuthorship W3009841123A5006176965 @default.
• W3009841123 hasAuthorship W3009841123A5021275777 @default.
• W3009841123 hasAuthorship W3009841123A5021719937 @default.
• W3009841123 hasAuthorship W3009841123A5032072845 @default.
• W3009841123 hasAuthorship W3009841123A5040491062 @default.
• W3009841123 hasAuthorship W3009841123A5047057307 @default.
• W3009841123 hasAuthorship W3009841123A5049637651 @default.
• W3009841123 hasAuthorship W3009841123A5054103832 @default.
• W3009841123 hasAuthorship W3009841123A5071763026 @default.
• W3009841123 hasAuthorship W3009841123A5080666019 @default.
• W3009841123 hasBestOaLocation W30098411231 @default.
• W3009841123 hasConcept C116581196 @default.
• W3009841123 hasConcept C11960822 @default.
• W3009841123 hasConcept C134018914 @default.
• W3009841123 hasConcept C137738243 @default.
• W3009841123 hasConcept C146727910 @default.
• W3009841123 hasConcept C1491633281 @default.
• W3009841123 hasConcept C151166631 @default.
• W3009841123 hasConcept C181199279 @default.
• W3009841123 hasConcept C207332259 @default.
• W3009841123 hasConcept C2779201268 @default.
• W3009841123 hasConcept C2779717556 @default.
• W3009841123 hasConcept C2780040266 @default.
• W3009841123 hasConcept C4733338 @default.
• W3009841123 hasConcept C48289651 @default.
• W3009841123 hasConcept C502942594 @default.
• W3009841123 hasConcept C55493867 @default.
• W3009841123 hasConcept C62478195 @default.
• W3009841123 hasConcept C85789140 @default.
• W3009841123 hasConcept C86803240 @default.
• W3009841123 hasConcept C95444343 @default.
• W3009841123 hasConceptScore W3009841123C116581196 @default.
• W3009841123 hasConceptScore W3009841123C11960822 @default.
• W3009841123 hasConceptScore W3009841123C134018914 @default.
• W3009841123 hasConceptScore W3009841123C137738243 @default.
• W3009841123 hasConceptScore W3009841123C146727910 @default.
• W3009841123 hasConceptScore W3009841123C1491633281 @default.
• W3009841123 hasConceptScore W3009841123C151166631 @default.
• W3009841123 hasConceptScore W3009841123C181199279 @default.
• W3009841123 hasConceptScore W3009841123C207332259 @default.
• W3009841123 hasConceptScore W3009841123C2779201268 @default.
• W3009841123 hasConceptScore W3009841123C2779717556 @default.
• W3009841123 hasConceptScore W3009841123C2780040266 @default.

• next