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- W3009940503 abstract "The sinoatrial node is perhaps one of the most important tissues in the entire body: it is the natural pacemaker of the heart, making it responsible for initiating each-and-every normal heartbeat. As such, its activity is heavily controlled, allowing heart rate to rapidly adapt to changes in physiological demand. Control of sinoatrial node activity, however, is complex, occurring through the autonomic nervous system and various circulating and locally released factors. In this review we discuss the coupled-clock pacemaker system and how its manipulation by neurohumoral signaling alters heart rate, considering the multitude of canonical and non-canonical agents that are known to modulate sinoatrial node activity. For each, we discuss the principal receptors involved and known intracellular signaling and protein targets, highlighting gaps in our knowledge and understanding from experimental models and human studies that represent areas for future research." @default.
- W3009940503 created "2020-03-13" @default.
- W3009940503 creator A5006293602 @default.
- W3009940503 creator A5066354737 @default.
- W3009940503 creator A5073006692 @default.
- W3009940503 date "2020-03-03" @default.
- W3009940503 modified "2023-10-10" @default.
- W3009940503 title "Neurohumoral Control of Sinoatrial Node Activity and Heart Rate: Insight From Experimental Models and Findings From Humans" @default.
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