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- W3009946287 endingPage "633" @default.
- W3009946287 startingPage "633" @default.
- W3009946287 abstract "Microalgae exhibit great potential for recombinant therapeutic protein production, due to lower production costs, immunity to human pathogens, and advanced genetic toolkits. However, a fundamental aspect to consider for recombinant biopharmaceutical production is the presence of correct post-translational modifications. Multiple recent studies focusing on glycosylation in microalgae have revealed unique species-specific patterns absent in humans. Glycosylation is particularly important for protein function and is directly responsible for recombinant biopharmaceutical immunogenicity. Therefore, it is necessary to fully characterise this key feature in microalgae before these organisms can be established as industrially relevant microbial biofactories. Here, we review the work done to date on production of recombinant biopharmaceuticals in microalgae, experimental and computational evidence for N- and O-glycosylation in diverse microalgal groups, established approaches for glyco-engineering, and perspectives for their application in microalgal systems. The insights from this review may be applied to future glyco-engineering attempts to humanize recombinant therapeutic proteins and to potentially obtain cheaper, fully functional biopharmaceuticals from microalgae." @default.
- W3009946287 created "2020-03-13" @default.
- W3009946287 creator A5002641865 @default.
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- W3009946287 creator A5082467149 @default.
- W3009946287 date "2020-03-05" @default.
- W3009946287 modified "2023-10-17" @default.
- W3009946287 title "Perspectives for Glyco-Engineering of Recombinant Biopharmaceuticals from Microalgae" @default.
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