Matches in SemOpenAlex for { <https://semopenalex.org/work/W3009972102> ?p ?o ?g. }
- W3009972102 abstract "Chemosensitization is an effective strategy to overcome the drawbacks of arsenic trioxide (As2O3) treatment which may be possible through the use of dietary supplements in combination. The present investigation evaluates the synergistic mechanism of action of L-Ascorbic acid (L-AA) and α-Tocopherol in As2O3 chemotherapy using human leukemia (HL-60) cells as an in vitro model. In vitro assays on the cytotoxicity of As2O3 and vitamins and cellular apoptotic evidences were done; a proteomic investigation with mass spectrometry was also performed. The combination of L-AA and α-TOC potentiates As2O3 cytotoxicity in HL-60 cells, substantiated by depletion in antioxidant status, mitochondrial transmembrane potential, and inhibition of Nuclear factor erythroid 2–related factor 2 (Nrf2) and B-cell lymphoma 2 (Bcl2) transcription factors. Mass spectrometry results showed decreased expression of proteins regulating cell cycle and translation in cells treated with As2O3, L-AA and α-TOC when compared with samples treated with As2O3 alone. Many proteins associated with apoptosis and cell stress were also identified following exposure to this combination treatment. HL-60 cells became more susceptible to As2O3 in the presence of L-AA and α-TOC indicating that this combination may be a promising approach to increase the outcome of arsenic trioxide chemotherapy." @default.
- W3009972102 created "2020-03-13" @default.
- W3009972102 creator A5013310684 @default.
- W3009972102 creator A5019490910 @default.
- W3009972102 creator A5040006330 @default.
- W3009972102 creator A5051429729 @default.
- W3009972102 creator A5080909347 @default.
- W3009972102 date "2020-02-21" @default.
- W3009972102 modified "2023-10-18" @default.
- W3009972102 title "L-Ascorbic Acid and α-Tocopherol Synergistically Triggers Apoptosis Inducing Antileukemic Effects of Arsenic Trioxide via Oxidative Stress in Human Acute Promyelocytic Leukemia Cells" @default.
- W3009972102 cites W11654018 @default.
- W3009972102 cites W134636856 @default.
- W3009972102 cites W1534823462 @default.
- W3009972102 cites W1599342152 @default.
- W3009972102 cites W1872445023 @default.
- W3009972102 cites W1931891535 @default.
- W3009972102 cites W1940935006 @default.
- W3009972102 cites W1968045891 @default.
- W3009972102 cites W1969418532 @default.
- W3009972102 cites W1979256423 @default.
- W3009972102 cites W1982961577 @default.
- W3009972102 cites W1986153062 @default.
- W3009972102 cites W1988740497 @default.
- W3009972102 cites W1991842062 @default.
- W3009972102 cites W1998948328 @default.
- W3009972102 cites W1999349182 @default.
- W3009972102 cites W2004556005 @default.
- W3009972102 cites W2012253608 @default.
- W3009972102 cites W2021103288 @default.
- W3009972102 cites W2029744518 @default.
- W3009972102 cites W2031909042 @default.
- W3009972102 cites W2038691856 @default.
- W3009972102 cites W2049457454 @default.
- W3009972102 cites W2052488557 @default.
- W3009972102 cites W2056416063 @default.
- W3009972102 cites W2069132215 @default.
- W3009972102 cites W2070640117 @default.
- W3009972102 cites W2070769983 @default.
- W3009972102 cites W2076935230 @default.
- W3009972102 cites W2079184489 @default.
- W3009972102 cites W2088104197 @default.
- W3009972102 cites W2093824108 @default.
- W3009972102 cites W2096795975 @default.
- W3009972102 cites W2096876385 @default.
- W3009972102 cites W2123724074 @default.
- W3009972102 cites W2128635872 @default.
- W3009972102 cites W2137449164 @default.
- W3009972102 cites W2144924497 @default.
- W3009972102 cites W2148855953 @default.
- W3009972102 cites W2151347057 @default.
- W3009972102 cites W2160359265 @default.
- W3009972102 cites W2163032093 @default.
- W3009972102 cites W2165935184 @default.
- W3009972102 cites W2409883671 @default.
- W3009972102 cites W2781553010 @default.
- W3009972102 cites W2801573780 @default.
- W3009972102 cites W4293247451 @default.
- W3009972102 doi "https://doi.org/10.3389/fonc.2020.00065" @default.
- W3009972102 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7047343" @default.
- W3009972102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32154163" @default.
- W3009972102 hasPublicationYear "2020" @default.
- W3009972102 type Work @default.
- W3009972102 sameAs 3009972102 @default.
- W3009972102 citedByCount "9" @default.
- W3009972102 countsByYear W30099721022020 @default.
- W3009972102 countsByYear W30099721022021 @default.
- W3009972102 countsByYear W30099721022022 @default.
- W3009972102 countsByYear W30099721022023 @default.
- W3009972102 crossrefType "journal-article" @default.
- W3009972102 hasAuthorship W3009972102A5013310684 @default.
- W3009972102 hasAuthorship W3009972102A5019490910 @default.
- W3009972102 hasAuthorship W3009972102A5040006330 @default.
- W3009972102 hasAuthorship W3009972102A5051429729 @default.
- W3009972102 hasAuthorship W3009972102A5080909347 @default.
- W3009972102 hasBestOaLocation W30099721021 @default.
- W3009972102 hasConcept C104317684 @default.
- W3009972102 hasConcept C109316439 @default.
- W3009972102 hasConcept C185592680 @default.
- W3009972102 hasConcept C190283241 @default.
- W3009972102 hasConcept C202751555 @default.
- W3009972102 hasConcept C2776151105 @default.
- W3009972102 hasConcept C2776601000 @default.
- W3009972102 hasConcept C2778004101 @default.
- W3009972102 hasConcept C2780386689 @default.
- W3009972102 hasConcept C2781121885 @default.
- W3009972102 hasConcept C2986274086 @default.
- W3009972102 hasConcept C31903555 @default.
- W3009972102 hasConcept C502942594 @default.
- W3009972102 hasConcept C55493867 @default.
- W3009972102 hasConcept C86803240 @default.
- W3009972102 hasConcept C98274493 @default.
- W3009972102 hasConceptScore W3009972102C104317684 @default.
- W3009972102 hasConceptScore W3009972102C109316439 @default.
- W3009972102 hasConceptScore W3009972102C185592680 @default.
- W3009972102 hasConceptScore W3009972102C190283241 @default.
- W3009972102 hasConceptScore W3009972102C202751555 @default.
- W3009972102 hasConceptScore W3009972102C2776151105 @default.
- W3009972102 hasConceptScore W3009972102C2776601000 @default.
- W3009972102 hasConceptScore W3009972102C2778004101 @default.
- W3009972102 hasConceptScore W3009972102C2780386689 @default.