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- W3009999284 abstract "Telomeres play an important role to conserve genomic integrity by protecting the ends of chromosomes in normal cells. Since, their progressive shortening during successive cell division which lead to chromosomal instability. Notably, telomere length is perpetuated by telomerase in large majority of cancers, thereby ensure indefinite cell proliferation-a hallmark of cancer-and this unique feature has provided telomerase as the preferred target for drug development in cancer therapeutics. Cancer cells have acquired the potential to have telomere length maintenance by telomerase activation- up-regulation of hTERT gene expression in tumor cells is synchronized by multiple genetic and epigenetic modification mechanisms viz hTERT structural variants, hTERT promoter mutation and epigenetic modifications through hTERT promoter methylation which have been implicated in various cancers initiation and progression. In view of these facts, strategies have been made to target the underlining molecular mechanisms involved in telomerase reactivation as well as of telomere structure with special reference to distortion of sheltrin proteins. This review is focussed on extensive understanding of telomere and telomerase biology. which will provide indispensable informations for enhancing the efficiency of rational anticancer drug design. However, there is also an urgent need for better understanding of cell signalling pathways for alternative lengthening of telomere which is present in telomerase negative cancer for therapeutic targets." @default.
- W3009999284 created "2020-03-13" @default.
- W3009999284 creator A5007588279 @default.
- W3009999284 creator A5013961815 @default.
- W3009999284 creator A5079405785 @default.
- W3009999284 date "2020-03-10" @default.
- W3009999284 modified "2023-10-16" @default.
- W3009999284 title "Therapeutic Targets in Telomerase and Telomere Biology of Cancers" @default.
- W3009999284 cites W1443307322 @default.
- W3009999284 cites W1521418395 @default.
- W3009999284 cites W1553644198 @default.
- W3009999284 cites W1556214569 @default.
- W3009999284 cites W1562677361 @default.
- W3009999284 cites W1643480200 @default.
- W3009999284 cites W1756506111 @default.
- W3009999284 cites W184964999 @default.
- W3009999284 cites W1969217042 @default.
- W3009999284 cites W1970555729 @default.
- W3009999284 cites W1970595490 @default.
- W3009999284 cites W1971503458 @default.
- W3009999284 cites W1971684179 @default.
- W3009999284 cites W1976882718 @default.
- W3009999284 cites W1977476599 @default.
- W3009999284 cites W1981358003 @default.
- W3009999284 cites W1982199027 @default.
- W3009999284 cites W1982904230 @default.
- W3009999284 cites W1984374449 @default.
- W3009999284 cites W1986009297 @default.
- W3009999284 cites W1987294642 @default.
- W3009999284 cites W1991934695 @default.
- W3009999284 cites W1994192533 @default.
- W3009999284 cites W1995541635 @default.
- W3009999284 cites W1997141870 @default.
- W3009999284 cites W1997316701 @default.
- W3009999284 cites W1998314264 @default.
- W3009999284 cites W2004561527 @default.
- W3009999284 cites W2009186918 @default.
- W3009999284 cites W2010882280 @default.
- W3009999284 cites W2013073993 @default.
- W3009999284 cites W2015037479 @default.
- W3009999284 cites W2017098545 @default.
- W3009999284 cites W2018618511 @default.
- W3009999284 cites W2020929647 @default.
- W3009999284 cites W2026180657 @default.
- W3009999284 cites W2027884659 @default.
- W3009999284 cites W2028147887 @default.
- W3009999284 cites W2029969982 @default.
- W3009999284 cites W2030209169 @default.
- W3009999284 cites W2030570157 @default.
- W3009999284 cites W2040257851 @default.
- W3009999284 cites W2041527069 @default.
- W3009999284 cites W2043740004 @default.
- W3009999284 cites W2043764151 @default.
- W3009999284 cites W2044485780 @default.
- W3009999284 cites W2045702252 @default.
- W3009999284 cites W2053430492 @default.
- W3009999284 cites W2053620236 @default.
- W3009999284 cites W2054383392 @default.
- W3009999284 cites W2058319585 @default.
- W3009999284 cites W2058375396 @default.
- W3009999284 cites W2060043441 @default.
- W3009999284 cites W2062395030 @default.
- W3009999284 cites W2062779626 @default.
- W3009999284 cites W2065766937 @default.
- W3009999284 cites W2073343115 @default.
- W3009999284 cites W2078805336 @default.
- W3009999284 cites W2086992094 @default.
- W3009999284 cites W2090526557 @default.
- W3009999284 cites W2094056217 @default.
- W3009999284 cites W2100215079 @default.
- W3009999284 cites W2101014559 @default.
- W3009999284 cites W2102490688 @default.
- W3009999284 cites W2103899181 @default.
- W3009999284 cites W2104500293 @default.
- W3009999284 cites W2106037418 @default.
- W3009999284 cites W2108503708 @default.
- W3009999284 cites W2109975152 @default.
- W3009999284 cites W2111171904 @default.
- W3009999284 cites W2111458920 @default.
- W3009999284 cites W2114773424 @default.
- W3009999284 cites W2117692326 @default.
- W3009999284 cites W2122740168 @default.
- W3009999284 cites W2122914216 @default.
- W3009999284 cites W2123105653 @default.
- W3009999284 cites W2125663907 @default.
- W3009999284 cites W2128211373 @default.
- W3009999284 cites W2133349879 @default.
- W3009999284 cites W2134786208 @default.
- W3009999284 cites W2139030264 @default.
- W3009999284 cites W2139893790 @default.
- W3009999284 cites W2146138017 @default.
- W3009999284 cites W2146975106 @default.
- W3009999284 cites W2149136779 @default.
- W3009999284 cites W2160185049 @default.
- W3009999284 cites W2161245725 @default.
- W3009999284 cites W2164389045 @default.
- W3009999284 cites W2164580633 @default.
- W3009999284 cites W2164841256 @default.