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• W3010007663 abstract "Abstract Three-dimensional (3D) structures of the genome are dynamic, heterogeneous and functionally important. Live cell imaging has become the leading method for chromatin dynamics tracking. However, existing CRISPR- and TALE-based genomic labeling techniques have been hampered by laborious protocols and are ineffective in labeling non-repetitive sequences. Here, we report a versatile CRISPR/Casilio-based imaging method that allows for a nonrepetitive genomic locus to be labeled using one guide RNA. We construct Casilio dual-color probes to visualize the dynamic interactions of DNA elements in single live cells in the presence or absence of the cohesin subunit RAD21. Using a three-color palette, we track the dynamic 3D locations of multiple reference points along a chromatin loop. Casilio imaging reveals intercellular heterogeneity and interallelic asynchrony in chromatin interaction dynamics, underscoring the importance of studying genome structures in 4D." @default.
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• W3010007663 date "2020-03-05" @default.
• W3010007663 modified "2023-09-23" @default.
• W3010007663 title "CRISPR-mediated Multiplexed Live Cell Imaging of Nonrepetitive Genomic Loci" @default.
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• W3010007663 doi "https://doi.org/10.1101/2020.03.03.974923" @default.
• W3010007663 hasPublicationYear "2020" @default.
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