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- W3010010399 endingPage "965" @default.
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- W3010010399 abstract "General anesthetics are a class of drugs that target the central nervous system and are widely used for various medical procedures. General anesthetics produce many behavioral changes required for clinical intervention, including amnesia, hypnosis, analgesia, and immobility; while they may also induce side effects like respiration and cardiovascular depressions. Understanding the mechanism of general anesthesia is essential for the development of selective general anesthetics which can preserve wanted pharmacological actions and exclude the side effects and underlying neural toxicities. However, the exact mechanism of how general anesthetics work is still elusive. Various molecular targets have been identified as specific targets for general anesthetics. Among these molecular targets, ion channels are the most principal category, including ligand-gated ionotropic receptors like γ-aminobutyric acid, glutamate and acetylcholine receptors, voltage-gated ion channels like voltage-gated sodium channel, calcium channel and potassium channels, and some second massager coupled channels. For neural functions of the central nervous system, synaptic transmission is the main procedure for which information is transmitted between neurons through brain regions, and intact synaptic function is fundamentally important for almost all the nervous functions, including consciousness, memory, and cognition. Therefore, it is important to understand the effects of general anesthetics on synaptic transmission via modulations of specific ion channels and relevant molecular targets, which can lead to the development of safer general anesthetics with selective actions. The present review will summarize the effects of various general anesthetics on synaptic transmissions and plasticity." @default.
- W3010010399 created "2020-03-13" @default.
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- W3010010399 date "2020-11-04" @default.
- W3010010399 modified "2023-10-14" @default.
- W3010010399 title "The Effects of General Anesthetics on Synaptic Transmission" @default.
- W3010010399 cites W1145655808 @default.
- W3010010399 cites W1497034990 @default.
- W3010010399 cites W1510423389 @default.
- W3010010399 cites W1527356837 @default.
- W3010010399 cites W1533662699 @default.
- W3010010399 cites W1533969500 @default.
- W3010010399 cites W1541419413 @default.
- W3010010399 cites W1565010155 @default.
- W3010010399 cites W1569936738 @default.
- W3010010399 cites W1581467941 @default.
- W3010010399 cites W1590163747 @default.
- W3010010399 cites W1594046881 @default.
- W3010010399 cites W1599426874 @default.
- W3010010399 cites W1600620818 @default.
- W3010010399 cites W1668093331 @default.
- W3010010399 cites W1797134060 @default.
- W3010010399 cites W1821749400 @default.
- W3010010399 cites W1822252127 @default.
- W3010010399 cites W1828079137 @default.
- W3010010399 cites W1856838339 @default.
- W3010010399 cites W1946447667 @default.
- W3010010399 cites W1963639011 @default.
- W3010010399 cites W1965312652 @default.
- W3010010399 cites W1966782538 @default.
- W3010010399 cites W1968069991 @default.
- W3010010399 cites W1968685262 @default.
- W3010010399 cites W1968903551 @default.
- W3010010399 cites W1970499295 @default.
- W3010010399 cites W1971368231 @default.
- W3010010399 cites W1972287815 @default.
- W3010010399 cites W1972690034 @default.
- W3010010399 cites W1973053815 @default.
- W3010010399 cites W1973361899 @default.
- W3010010399 cites W1974067040 @default.
- W3010010399 cites W1975506521 @default.
- W3010010399 cites W1975535985 @default.
- W3010010399 cites W1975677874 @default.
- W3010010399 cites W1976034037 @default.
- W3010010399 cites W1976095999 @default.
- W3010010399 cites W1976122996 @default.
- W3010010399 cites W1976479871 @default.
- W3010010399 cites W1977584840 @default.
- W3010010399 cites W1977742032 @default.
- W3010010399 cites W1979560116 @default.
- W3010010399 cites W1980176764 @default.
- W3010010399 cites W1980325410 @default.
- W3010010399 cites W1980963309 @default.
- W3010010399 cites W1982466768 @default.
- W3010010399 cites W1982488830 @default.
- W3010010399 cites W1983187084 @default.
- W3010010399 cites W1983663503 @default.
- W3010010399 cites W1983756509 @default.
- W3010010399 cites W1984566757 @default.
- W3010010399 cites W1984574127 @default.
- W3010010399 cites W1984855706 @default.
- W3010010399 cites W1985241009 @default.
- W3010010399 cites W1985398371 @default.
- W3010010399 cites W1985673618 @default.
- W3010010399 cites W1986291163 @default.
- W3010010399 cites W1986589714 @default.
- W3010010399 cites W1986860620 @default.
- W3010010399 cites W1987508280 @default.
- W3010010399 cites W1988323645 @default.
- W3010010399 cites W1988386975 @default.
- W3010010399 cites W1988452935 @default.
- W3010010399 cites W1988782252 @default.
- W3010010399 cites W1989663858 @default.
- W3010010399 cites W1991250636 @default.
- W3010010399 cites W1991719024 @default.
- W3010010399 cites W1991919940 @default.
- W3010010399 cites W1992682622 @default.
- W3010010399 cites W1992693738 @default.
- W3010010399 cites W1993251602 @default.
- W3010010399 cites W1993379308 @default.
- W3010010399 cites W1993584057 @default.
- W3010010399 cites W1995021042 @default.
- W3010010399 cites W1995886761 @default.
- W3010010399 cites W1997529256 @default.
- W3010010399 cites W1997956229 @default.
- W3010010399 cites W1998802012 @default.
- W3010010399 cites W1999213641 @default.
- W3010010399 cites W1999423218 @default.
- W3010010399 cites W1999829442 @default.