FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010013013> ?p ?o ?g. }

• W3010013013 endingPage "29" @default.
• W3010013013 startingPage "20" @default.
• W3010013013 abstract "Melanoma is one of the most aggressive and high mortality skin cancers in the world. Long non-coding RNA-CASC15, as a carcinogen, plays an important role in a variety of tumorigenesis; however, the role and underlying mechanism of CASC15 in melanoma remain unclear.Quantitative real-time polymerase chain reaction was applied to explore CASC15 and β-catenin expression in melanoma tissues and cells. Western blotting was carried out to investigate β-catenin, glycogen synthase kinase-3β, Survivin, Bax, Bcl-2, and epithelial-mesenchymal transition (EMT)-related protein expression level. Cell proliferation, apoptosis, migration, and invasion were observed by colony formation assay, flow cytometry, and transwell migration and invasion assays, respectively. The activity of Wnt/β-catenin signaling pathway was measured by Topflash luciferase reporter assay.The expression of CASC15 and β-catenin was upregulated in melanoma tissues and cells. Knockdown of CASC15 suppressed Wnt/β-catenin signaling pathway and inhibited β-catenin expression. Furthermore, inhibition of CASC15 decreased proliferation and increased apoptosis of melanoma cells by downregulating Survivin and Bcl-2 and upregulating Bax in A375 and SK-MEL-28 cells. Silencing of CASC15 inhibited migration and invasion of melanoma cells by repressing EMT process.Our study demonstrated that CASC15 promoted the proliferation, migration, and invasion of melanoma cells via activating Wnt/β-catenin signaling pathway, implying that CASC15 might be a potential therapeutic target and prognostic biomarker for melanoma." @default.
• W3010013013 created "2020-03-13" @default.
• W3010013013 creator A5034990215 @default.
• W3010013013 creator A5082881860 @default.
• W3010013013 date "2019-12-13" @default.
• W3010013013 modified "2023-10-16" @default.
• W3010013013 title "Long Non-Coding RNA-CASC15 Promotes Cell Proliferation, Migration, and Invasion by Activating Wnt/β-Catenin Signaling Pathway in Melanoma" @default.
• W3010013013 cites W1534512347 @default.
• W3010013013 cites W1859714693 @default.
• W3010013013 cites W2023145844 @default.
• W3010013013 cites W2049541774 @default.
• W3010013013 cites W2091161969 @default.
• W3010013013 cites W2104877706 @default.
• W3010013013 cites W2110957978 @default.
• W3010013013 cites W2165948908 @default.
• W3010013013 cites W2401641277 @default.
• W3010013013 cites W2559838833 @default.
• W3010013013 cites W2603473536 @default.
• W3010013013 cites W2737600680 @default.
• W3010013013 cites W2745634501 @default.
• W3010013013 cites W2756842203 @default.
• W3010013013 cites W2762347490 @default.
• W3010013013 cites W2766750844 @default.
• W3010013013 cites W2771184879 @default.
• W3010013013 cites W2789269408 @default.
• W3010013013 cites W2790457313 @default.
• W3010013013 cites W2809620628 @default.
• W3010013013 cites W2822355198 @default.
• W3010013013 cites W2884299577 @default.
• W3010013013 cites W2899513871 @default.
• W3010013013 cites W2909433939 @default.
• W3010013013 cites W2911188335 @default.
• W3010013013 cites W4240458912 @default.
• W3010013013 doi "https://doi.org/10.1159/000502803" @default.
• W3010013013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31838468" @default.
• W3010013013 hasPublicationYear "2019" @default.
• W3010013013 type Work @default.
• W3010013013 sameAs 3010013013 @default.
• W3010013013 citedByCount "19" @default.
• W3010013013 countsByYear W30100130132020 @default.
• W3010013013 countsByYear W30100130132021 @default.
• W3010013013 countsByYear W30100130132022 @default.
• W3010013013 countsByYear W30100130132023 @default.
• W3010013013 crossrefType "journal-article" @default.
• W3010013013 hasAuthorship W3010013013A5034990215 @default.
• W3010013013 hasAuthorship W3010013013A5082881860 @default.
• W3010013013 hasConcept C104317684 @default.
• W3010013013 hasConcept C121608353 @default.
• W3010013013 hasConcept C127561419 @default.
• W3010013013 hasConcept C137620995 @default.
• W3010013013 hasConcept C173396325 @default.
• W3010013013 hasConcept C190283241 @default.
• W3010013013 hasConcept C2775975398 @default.
• W3010013013 hasConcept C2777658100 @default.
• W3010013013 hasConcept C502942594 @default.
• W3010013013 hasConcept C54355233 @default.
• W3010013013 hasConcept C55493867 @default.
• W3010013013 hasConcept C555283112 @default.
• W3010013013 hasConcept C62112901 @default.
• W3010013013 hasConcept C62478195 @default.
• W3010013013 hasConcept C76419328 @default.
• W3010013013 hasConcept C86803240 @default.
• W3010013013 hasConcept C95444343 @default.
• W3010013013 hasConceptScore W3010013013C104317684 @default.
• W3010013013 hasConceptScore W3010013013C121608353 @default.
• W3010013013 hasConceptScore W3010013013C127561419 @default.
• W3010013013 hasConceptScore W3010013013C137620995 @default.
• W3010013013 hasConceptScore W3010013013C173396325 @default.
• W3010013013 hasConceptScore W3010013013C190283241 @default.
• W3010013013 hasConceptScore W3010013013C2775975398 @default.
• W3010013013 hasConceptScore W3010013013C2777658100 @default.
• W3010013013 hasConceptScore W3010013013C502942594 @default.
• W3010013013 hasConceptScore W3010013013C54355233 @default.
• W3010013013 hasConceptScore W3010013013C55493867 @default.
• W3010013013 hasConceptScore W3010013013C555283112 @default.
• W3010013013 hasConceptScore W3010013013C62112901 @default.
• W3010013013 hasConceptScore W3010013013C62478195 @default.
• W3010013013 hasConceptScore W3010013013C76419328 @default.
• W3010013013 hasConceptScore W3010013013C86803240 @default.
• W3010013013 hasConceptScore W3010013013C95444343 @default.
• W3010013013 hasIssue "1" @default.
• W3010013013 hasLocation W30100130131 @default.
• W3010013013 hasLocation W30100130132 @default.
• W3010013013 hasOpenAccess W3010013013 @default.
• W3010013013 hasPrimaryLocation W30100130131 @default.
• W3010013013 hasRelatedWork W178543369 @default.
• W3010013013 hasRelatedWork W1993745051 @default.
• W3010013013 hasRelatedWork W2159271922 @default.
• W3010013013 hasRelatedWork W2367667778 @default.
• W3010013013 hasRelatedWork W2374067319 @default.
• W3010013013 hasRelatedWork W2810269284 @default.
• W3010013013 hasRelatedWork W2966355304 @default.
• W3010013013 hasRelatedWork W3080520129 @default.
• W3010013013 hasRelatedWork W3105659513 @default.
• W3010013013 hasRelatedWork W4378696516 @default.
• W3010013013 hasVolume "87" @default.
• W3010013013 isParatext "false" @default.
• W3010013013 isRetracted "false" @default.

• next