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• W3010025196 abstract "Abstract Background Emerging evidence has shown that vitamin D and magnesium have anti-inflammatory and anti-depressant effects. Dietary intake of magnesium is associated with reduced body mass index, waist circumference, body fat percentage, as well as inflammatory biomarkers and depressive symptoms. Vitamin D deficiency has been linked to inflammation, obesity, and depressive symptoms. This study will test the effects of vitamin D and magnesium co-supplementation on mood, serum level of brain-derived neurotrophic factor (BDNF), inflammation, and sirtuin 1 (SIRT1) in obese women. Methods We will conduct an 8-week, double-blind, randomized, placebo-controlled clinical trial, in a factorial design, to evaluate the individual effects of vitamin D and magnesium, and co-supplementation of them, on mood, serum level of BDNF, inflammation, and SIRT1 in 108 obese women. Discussion We hypothesize that vitamin D and magnesium co-supplementation may provide a new adjuvant therapy through modulation of BDNF, inflammation, and SIRT1 in obese women. Trial registration Iranian Registry of Clinical Trials, IRCT20090822002365N23 . Registered on 16 August 2019." @default.
• W3010025196 created "2020-03-13" @default.
• W3010025196 creator A5010075023 @default.
• W3010025196 creator A5083269633 @default.
• W3010025196 date "2020-02-26" @default.
• W3010025196 modified "2023-09-27" @default.
• W3010025196 title "Effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammatory biomarkers, and SIRT1 in obese women: a study protocol for a double-blind, randomized, placebo-controlled trial" @default.
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• W3010025196 doi "https://doi.org/10.1186/s13063-020-4122-9" @default.
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