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- W3010028900 abstract "Abstract Background Short-chain fatty acids (SCFAs) play important physiological roles in human health. Adverse effects on health are known with a low or excessive concentration of SCFAs although the optimal level of SCFAs in the body is unknown yet. The level of endogenous SCFAs is affected by many factors of which gut bacteria are the most important one. However, how gut bacteria and a dietary intervention affect SCFA balance in the gut still needs to be clarified. Scope and approach In addition to addressing the importance of a dynamic balance of SCFAs for health, we discuss the factors affecting the dynamic balance of SCFAs, especially the gut SCFA-producing bacteria, including the classification of the bacteria, their response to diet, the SCFAs metabolic pathways and the catalytic mechanisms of the main rate-limiting enzymes. Key findings and conclusions SCFAs levels can be regulated endogenously and exogenously. Exogenous regulation delivers SCFAs to gut by esterification with dietary fibres. Endogenous regulation like diet, directly or indirectly affect gut microbiota, including their abundance, fitness and SCFAs production. Until now, 74 bacterial species are reported to produce SCFAs, the metabolic pathways are classified into 4 categories, and the 4 rate-limiting enzymes in the metabolic pathways are summarized. We also propose methods for long-lasting endogenous SCFAs balancing, including identifying the minimum sets of SCFA-producing bacterial group, and possible dietary intervention to form a minimum group of gut microbiota for SCFAs synthesis. An integrated approach will help realize the rational regulation of balanced SCFAs levels to benefit human health." @default.
- W3010028900 created "2020-03-13" @default.
- W3010028900 creator A5012265390 @default.
- W3010028900 creator A5042063397 @default.
- W3010028900 creator A5042453299 @default.
- W3010028900 creator A5059377637 @default.
- W3010028900 date "2020-06-01" @default.
- W3010028900 modified "2023-10-14" @default.
- W3010028900 title "Dynamic balancing of intestinal short-chain fatty acids: The crucial role of bacterial metabolism" @default.
- W3010028900 cites W1105433215 @default.
- W3010028900 cites W1489354328 @default.
- W3010028900 cites W1490851253 @default.
- W3010028900 cites W1745801738 @default.
- W3010028900 cites W1790787093 @default.
- W3010028900 cites W1833538045 @default.
- W3010028900 cites W1966094758 @default.
- W3010028900 cites W1978119727 @default.
- W3010028900 cites W1982715293 @default.
- W3010028900 cites W1985276456 @default.
- W3010028900 cites W1990590570 @default.
- W3010028900 cites W1995992551 @default.
- W3010028900 cites W1996195646 @default.
- W3010028900 cites W2008016941 @default.
- W3010028900 cites W2008095174 @default.
- W3010028900 cites W2010654843 @default.
- W3010028900 cites W2010837850 @default.
- W3010028900 cites W2011995221 @default.
- W3010028900 cites W2012259041 @default.
- W3010028900 cites W2023089746 @default.
- W3010028900 cites W2031355202 @default.
- W3010028900 cites W2033239478 @default.
- W3010028900 cites W2035000550 @default.
- W3010028900 cites W2035235145 @default.
- W3010028900 cites W2050920580 @default.
- W3010028900 cites W2051312690 @default.
- W3010028900 cites W2052358964 @default.
- W3010028900 cites W2052547316 @default.
- W3010028900 cites W2057604623 @default.
- W3010028900 cites W2060185417 @default.
- W3010028900 cites W2062179619 @default.
- W3010028900 cites W2078770291 @default.
- W3010028900 cites W2096737257 @default.
- W3010028900 cites W2096929238 @default.
- W3010028900 cites W2098762803 @default.
- W3010028900 cites W2101209169 @default.
- W3010028900 cites W2106348916 @default.
- W3010028900 cites W2110936821 @default.
- W3010028900 cites W2113678392 @default.
- W3010028900 cites W2113705577 @default.
- W3010028900 cites W2116595065 @default.
- W3010028900 cites W2116846792 @default.
- W3010028900 cites W2117595393 @default.
- W3010028900 cites W2118635437 @default.
- W3010028900 cites W2124424637 @default.
- W3010028900 cites W2126559542 @default.
- W3010028900 cites W2128898932 @default.
- W3010028900 cites W2131902769 @default.
- W3010028900 cites W2133562922 @default.
- W3010028900 cites W2133764438 @default.
- W3010028900 cites W2134176478 @default.
- W3010028900 cites W2136500114 @default.
- W3010028900 cites W2138842934 @default.
- W3010028900 cites W2142251632 @default.
- W3010028900 cites W2144754352 @default.
- W3010028900 cites W2145465660 @default.
- W3010028900 cites W2148448906 @default.
- W3010028900 cites W2149515881 @default.
- W3010028900 cites W2153832854 @default.
- W3010028900 cites W2153931937 @default.
- W3010028900 cites W2159924324 @default.
- W3010028900 cites W2166562121 @default.
- W3010028900 cites W2166569595 @default.
- W3010028900 cites W2170399343 @default.
- W3010028900 cites W2171016495 @default.
- W3010028900 cites W2210361504 @default.
- W3010028900 cites W2278335898 @default.
- W3010028900 cites W2298480753 @default.
- W3010028900 cites W2345813655 @default.
- W3010028900 cites W2409656339 @default.
- W3010028900 cites W2414820426 @default.
- W3010028900 cites W2417777372 @default.
- W3010028900 cites W2480559039 @default.
- W3010028900 cites W2504820542 @default.
- W3010028900 cites W2537449585 @default.
- W3010028900 cites W2545892218 @default.
- W3010028900 cites W2586574172 @default.
- W3010028900 cites W2765162182 @default.
- W3010028900 cites W2774675968 @default.
- W3010028900 cites W2783618680 @default.
- W3010028900 cites W2789495752 @default.
- W3010028900 cites W2790034894 @default.
- W3010028900 cites W2791576196 @default.
- W3010028900 cites W2885010107 @default.
- W3010028900 cites W2890189910 @default.
- W3010028900 cites W2904645217 @default.
- W3010028900 cites W2911616568 @default.
- W3010028900 cites W2913914265 @default.
- W3010028900 cites W2913972921 @default.