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- W3010033147 abstract "Understanding how chromatin is regulated is essential to fully grasp genome biology, and establishing the locus-specific protein composition is a major step toward this goal. Here we explain why the isolation and analysis of a specific chromatin segment are technically challenging, independently of the method. We then describe the published strategies and discuss their advantages and limitations. We conclude by discussing why significant technology developments are required to unambiguously describe the composition of small single loci. This Perspective discusses the challenges, progress and future of proteome profiling at specific chromatin loci for elucidating genome biology." @default.
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- W3010033147 date "2020-03-09" @default.
- W3010033147 modified "2023-10-18" @default.
- W3010033147 title "Purification and enrichment of specific chromatin loci" @default.
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- W3010033147 doi "https://doi.org/10.1038/s41592-020-0765-4" @default.
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