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- W3010068941 abstract "Supplemental arginine has shown promise as a safe therapeutic option to improve endogenous nitric oxide (NO) regulation in cardiovascular diseases associated with endothelial dysfunction. In clinical studies in adults, L-arginine, an endogenous amino acid, was reported to improve cardiovascular function in hypertension, pulmonary hypertension, preeclampsia, angina, and MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) syndrome. L-citrulline, a natural precursor of L-arginine, is more bioavailable than L-arginine because it avoids hepatic first-pass metabolism and has a longer circulation time. Although not yet well-studied, arginine/citrulline has immense therapeutic potential in some life-threatening diseases in children. However, the optimal clinical development of arginine or citrulline in children requires more information about pharmacokinetics and exposure-response relationships at appropriate ages and under relevant disease states. This article summarizes the preclinical and clinical studies of arginine/citrulline in both adults and children, including currently available pharmacokinetic information. The pharmacology of arginine/citrulline is confounded by several patient-specific factors such as variations in baseline arginine/citrulline due to developmental ages and disease states. Currently available pharmacokinetic studies are insufficient to inform the optimal design of clinical studies, especially in children. Successful bench-to-bedside clinical translation of arginine supplementation awaits information from well-designed pharmacokinetic/pharmacodynamic studies, along with pharmacometric approaches." @default.
- W3010068941 created "2020-03-13" @default.
- W3010068941 creator A5003154229 @default.
- W3010068941 creator A5017594091 @default.
- W3010068941 creator A5023547704 @default.
- W3010068941 creator A5052819935 @default.
- W3010068941 creator A5064776181 @default.
- W3010068941 creator A5083033053 @default.
- W3010068941 date "2020-03-06" @default.
- W3010068941 modified "2023-10-17" @default.
- W3010068941 title "Therapeutic Potential of Citrulline as an Arginine Supplement: A Clinical Pharmacology Review" @default.
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