Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010097703> ?p ?o ?g. }
- W3010097703 endingPage "53.e1" @default.
- W3010097703 startingPage "45" @default.
- W3010097703 abstract "Cyclin D1 (CCND1) overexpression is an early and unifying oncogenic event in mantle cell lymphoma (MCL) and multiple myeloma (MM) with chromosome 11q13 abnormalities. Herein, we report newly discovered transcript variants of the CCND1 gene in MCL and MM cells with chromosome 11q13 abnormalities. These transcript variants, designated CCND1.tv., covered the full-length coding region of CCND1 with longer 5'-untranslated regions (5'-UTRs) of CCND1 and occasionally contained a novel exon. CCND1.tv. was specifically detectable in patient-derived primary MCL or MM cells with chromosomal translocation t(11;14)(q13;q32), but not in t(11;14)-negative cells. The lengths of the 5'-UTR sequences of CCND1.tv. differed among patients and cell lines. Introduction of CCND1.tv. led to increased expression of normal-sized CCND1 protein in HEK293 cells. Furthermore, mTOR inhibition by rapamycin or serum starvation reduced ectopic expression of CCND1.tv.-derived CCND1 protein, but not 5'-UTR less CCND1-derived CCND1 protein in HEK293 cells, suggesting that the protein expression of CCND1.tv. is regulated by the mTOR pathway. Our results suggest that the aberrant expression of CCND1.tv. may contribute to the understanding of the pathogenesis of MCL and MM with 11q13 abnormalities." @default.
- W3010097703 created "2020-03-13" @default.
- W3010097703 creator A5002630298 @default.
- W3010097703 creator A5015449116 @default.
- W3010097703 creator A5024590228 @default.
- W3010097703 creator A5028457340 @default.
- W3010097703 creator A5030247129 @default.
- W3010097703 creator A5036112859 @default.
- W3010097703 creator A5039045560 @default.
- W3010097703 creator A5039257959 @default.
- W3010097703 creator A5039445832 @default.
- W3010097703 creator A5054037982 @default.
- W3010097703 creator A5054667160 @default.
- W3010097703 creator A5072434041 @default.
- W3010097703 creator A5076540249 @default.
- W3010097703 creator A5091147979 @default.
- W3010097703 date "2020-04-01" @default.
- W3010097703 modified "2023-10-17" @default.
- W3010097703 title "Tumor-specific transcript variants of cyclin D1 in mantle cell lymphoma and multiple myeloma with chromosome 11q13 abnormalities" @default.
- W3010097703 cites W1529372075 @default.
- W3010097703 cites W1608415194 @default.
- W3010097703 cites W1969492248 @default.
- W3010097703 cites W1974788142 @default.
- W3010097703 cites W1986625550 @default.
- W3010097703 cites W1988151490 @default.
- W3010097703 cites W1988238204 @default.
- W3010097703 cites W1988595759 @default.
- W3010097703 cites W1998324316 @default.
- W3010097703 cites W2001443196 @default.
- W3010097703 cites W2007215370 @default.
- W3010097703 cites W2008410413 @default.
- W3010097703 cites W2011961482 @default.
- W3010097703 cites W2012295982 @default.
- W3010097703 cites W2012902797 @default.
- W3010097703 cites W2015975538 @default.
- W3010097703 cites W2016975585 @default.
- W3010097703 cites W2038322120 @default.
- W3010097703 cites W2040669551 @default.
- W3010097703 cites W2042012882 @default.
- W3010097703 cites W2058365975 @default.
- W3010097703 cites W2062074928 @default.
- W3010097703 cites W2062299199 @default.
- W3010097703 cites W2062660352 @default.
- W3010097703 cites W2068473916 @default.
- W3010097703 cites W2072445382 @default.
- W3010097703 cites W2073733397 @default.
- W3010097703 cites W2078279944 @default.
- W3010097703 cites W2081224211 @default.
- W3010097703 cites W2090296060 @default.
- W3010097703 cites W2096979580 @default.
- W3010097703 cites W2109118704 @default.
- W3010097703 cites W2112067247 @default.
- W3010097703 cites W2112318168 @default.
- W3010097703 cites W2112431155 @default.
- W3010097703 cites W2127063807 @default.
- W3010097703 cites W2138655430 @default.
- W3010097703 cites W2151490972 @default.
- W3010097703 cites W2165848665 @default.
- W3010097703 cites W2295824326 @default.
- W3010097703 cites W2599252015 @default.
- W3010097703 doi "https://doi.org/10.1016/j.exphem.2020.02.004" @default.
- W3010097703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32145384" @default.
- W3010097703 hasPublicationYear "2020" @default.
- W3010097703 type Work @default.
- W3010097703 sameAs 3010097703 @default.
- W3010097703 citedByCount "3" @default.
- W3010097703 countsByYear W30100977032021 @default.
- W3010097703 countsByYear W30100977032022 @default.
- W3010097703 crossrefType "journal-article" @default.
- W3010097703 hasAuthorship W3010097703A5002630298 @default.
- W3010097703 hasAuthorship W3010097703A5015449116 @default.
- W3010097703 hasAuthorship W3010097703A5024590228 @default.
- W3010097703 hasAuthorship W3010097703A5028457340 @default.
- W3010097703 hasAuthorship W3010097703A5030247129 @default.
- W3010097703 hasAuthorship W3010097703A5036112859 @default.
- W3010097703 hasAuthorship W3010097703A5039045560 @default.
- W3010097703 hasAuthorship W3010097703A5039257959 @default.
- W3010097703 hasAuthorship W3010097703A5039445832 @default.
- W3010097703 hasAuthorship W3010097703A5054037982 @default.
- W3010097703 hasAuthorship W3010097703A5054667160 @default.
- W3010097703 hasAuthorship W3010097703A5072434041 @default.
- W3010097703 hasAuthorship W3010097703A5076540249 @default.
- W3010097703 hasAuthorship W3010097703A5091147979 @default.
- W3010097703 hasBestOaLocation W30100977031 @default.
- W3010097703 hasConcept C104317684 @default.
- W3010097703 hasConcept C105580179 @default.
- W3010097703 hasConcept C153911025 @default.
- W3010097703 hasConcept C199835354 @default.
- W3010097703 hasConcept C203014093 @default.
- W3010097703 hasConcept C2777525834 @default.
- W3010097703 hasConcept C2779338263 @default.
- W3010097703 hasConcept C29537977 @default.
- W3010097703 hasConcept C502942594 @default.
- W3010097703 hasConcept C54355233 @default.
- W3010097703 hasConcept C86803240 @default.
- W3010097703 hasConcept C89604277 @default.
- W3010097703 hasConcept C97037327 @default.
- W3010097703 hasConceptScore W3010097703C104317684 @default.