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• W3010103159 abstract "Physical or chemical crosslinking of polymeric micelles has emerged as a straightforward approach to overcome the intrinsic instability of assemblies. However, the crosslinking process may compromise the responsivity of nanosystems and result in inefficient release of payloads. To address this dilemma, a crosslinking induced reassembly (CIRA) strategy is reported here to simultaneously increase the kinetic and thermodynamic stability and redox-responsivity of polymeric micelles. It is found that the click crosslinking of a model multiblock polyurethane at the micellar interface induces microphase separation between the soft and hard segments. The aggregation of hard domains gathers liable disulfide linkages around the interlayer of micelles, which could facilitate the attack of reducing agents and act as an intelligent on-off switch for high stability and triggered release. As a result, the CIRA approach enables an enhanced tumor targeting, improved biodistribution and excellent therapeutic efficacy in vivo. This work provides a facile and versatile platform for controlled delivery applications." @default.
• W3010103159 created "2020-03-13" @default.
• W3010103159 creator A5000276945 @default.
• W3010103159 creator A5002164020 @default.
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• W3010103159 creator A5053424081 @default.
• W3010103159 creator A5055601502 @default.
• W3010103159 creator A5067793877 @default.
• W3010103159 date "2020-03-06" @default.
• W3010103159 modified "2023-10-14" @default.
• W3010103159 title "Crosslinking Induced Reassembly of Multiblock Polymers: Addressing the Dilemma of Stability and Responsivity" @default.
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• W3010103159 doi "https://doi.org/10.1002/advs.201902701" @default.
• W3010103159 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7175344" @default.
• W3010103159 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32328415" @default.
• W3010103159 hasPublicationYear "2020" @default.
• W3010103159 type Work @default.
• W3010103159 sameAs 3010103159 @default.

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