Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010116705> ?p ?o ?g. }
- W3010116705 endingPage "183.e5" @default.
- W3010116705 startingPage "168" @default.
- W3010116705 abstract "Crossover recombination is essential for accurate chromosome segregation during meiosis. The MutSγ complex, Msh4-Msh5, facilitates crossing over by binding and stabilizing nascent recombination intermediates. We show that these activities are governed by regulated proteolysis. MutSγ is initially inactive for crossing over due to an N-terminal degron on Msh4 that renders it unstable by directly targeting proteasomal degradation. Activation of MutSγ requires the Dbf4-dependent kinase Cdc7 (DDK), which directly phosphorylates and thereby neutralizes the Msh4 degron. Genetic requirements for Msh4 phosphorylation indicate that DDK targets MutSγ only after it has bound to nascent joint molecules (JMs) in the context of synapsing chromosomes. Overexpression studies confirm that the steady-state level of Msh4, not phosphorylation per se, is the critical determinant for crossing over. At the DNA level, Msh4 phosphorylation enables the formation and crossover-biased resolution of double-Holliday Junction intermediates. Our study establishes regulated protein degradation as a fundamental mechanism underlying meiotic crossing over." @default.
- W3010116705 created "2020-03-13" @default.
- W3010116705 creator A5002257517 @default.
- W3010116705 creator A5011827924 @default.
- W3010116705 creator A5012775206 @default.
- W3010116705 creator A5014934585 @default.
- W3010116705 creator A5021909684 @default.
- W3010116705 creator A5022714367 @default.
- W3010116705 creator A5024023733 @default.
- W3010116705 creator A5028068779 @default.
- W3010116705 creator A5028277342 @default.
- W3010116705 creator A5041592902 @default.
- W3010116705 creator A5043745359 @default.
- W3010116705 creator A5049116955 @default.
- W3010116705 creator A5054160947 @default.
- W3010116705 creator A5056096904 @default.
- W3010116705 creator A5067280218 @default.
- W3010116705 creator A5074405835 @default.
- W3010116705 creator A5084218805 @default.
- W3010116705 date "2020-04-01" @default.
- W3010116705 modified "2023-10-10" @default.
- W3010116705 title "Regulated Proteolysis of MutSγ Controls Meiotic Crossing Over" @default.
- W3010116705 cites W1136373239 @default.
- W3010116705 cites W1497947649 @default.
- W3010116705 cites W1856803525 @default.
- W3010116705 cites W1876047377 @default.
- W3010116705 cites W191863501 @default.
- W3010116705 cites W1966616557 @default.
- W3010116705 cites W1969367585 @default.
- W3010116705 cites W1969664012 @default.
- W3010116705 cites W1971201699 @default.
- W3010116705 cites W1971701485 @default.
- W3010116705 cites W1973507920 @default.
- W3010116705 cites W1981946886 @default.
- W3010116705 cites W1996118579 @default.
- W3010116705 cites W1996433893 @default.
- W3010116705 cites W1996599185 @default.
- W3010116705 cites W1997203731 @default.
- W3010116705 cites W1997606727 @default.
- W3010116705 cites W2002748750 @default.
- W3010116705 cites W2006319417 @default.
- W3010116705 cites W2017968505 @default.
- W3010116705 cites W2022577704 @default.
- W3010116705 cites W2022753514 @default.
- W3010116705 cites W2027226662 @default.
- W3010116705 cites W2027478659 @default.
- W3010116705 cites W2029856558 @default.
- W3010116705 cites W2031782420 @default.
- W3010116705 cites W2032852397 @default.
- W3010116705 cites W2035417449 @default.
- W3010116705 cites W2039781354 @default.
- W3010116705 cites W2041386953 @default.
- W3010116705 cites W2055869439 @default.
- W3010116705 cites W2059175716 @default.
- W3010116705 cites W2063358818 @default.
- W3010116705 cites W2064363195 @default.
- W3010116705 cites W2065271821 @default.
- W3010116705 cites W2066792579 @default.
- W3010116705 cites W2067305429 @default.
- W3010116705 cites W2070550063 @default.
- W3010116705 cites W2070650108 @default.
- W3010116705 cites W2073085152 @default.
- W3010116705 cites W2078743927 @default.
- W3010116705 cites W2082035728 @default.
- W3010116705 cites W2082471729 @default.
- W3010116705 cites W2086347537 @default.
- W3010116705 cites W2086745720 @default.
- W3010116705 cites W2089051395 @default.
- W3010116705 cites W2092097845 @default.
- W3010116705 cites W2093452293 @default.
- W3010116705 cites W2100057937 @default.
- W3010116705 cites W2100298442 @default.
- W3010116705 cites W2104131863 @default.
- W3010116705 cites W2106916923 @default.
- W3010116705 cites W2110548948 @default.
- W3010116705 cites W2114025338 @default.
- W3010116705 cites W2114171007 @default.
- W3010116705 cites W2116471216 @default.
- W3010116705 cites W2117421302 @default.
- W3010116705 cites W2123990952 @default.
- W3010116705 cites W2136144795 @default.
- W3010116705 cites W2137314232 @default.
- W3010116705 cites W2139705915 @default.
- W3010116705 cites W2143254936 @default.
- W3010116705 cites W2143396816 @default.
- W3010116705 cites W2143719385 @default.
- W3010116705 cites W2151137171 @default.
- W3010116705 cites W2151268228 @default.
- W3010116705 cites W2159372765 @default.
- W3010116705 cites W2161758325 @default.
- W3010116705 cites W2162317201 @default.
- W3010116705 cites W2184577967 @default.
- W3010116705 cites W2189387085 @default.
- W3010116705 cites W2213402634 @default.
- W3010116705 cites W2229607380 @default.
- W3010116705 cites W2305964290 @default.
- W3010116705 cites W2311644065 @default.
- W3010116705 cites W2401679077 @default.