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- W3010121256 endingPage "836" @default.
- W3010121256 startingPage "822" @default.
- W3010121256 abstract "Sinusoidal obstruction syndrome (SOS), previously known as hepatic veno-occlusive disease (VOD), remains a multi-organ system complication following haematopoietic cell transplantation (HCT). When SOS/VOD is accompanied by multi-organ dysfunction, overall mortality rates remain >80%. However, the definitions related to the diagnosis and grading of SOS/VOD after HCT are almost 25 years old and require new and contemporary modifications. Importantly, the pathophysiology of SOS/VOD, including the contribution of dysregulated inflammatory and coagulation cascades as well as the critical importance of liver and vascular derived endothelial dysfunction, have been elucidated. Here we summarise new information on pathogenesis of SOS/VOD; identify modifiable and unmodifiable risk factors for disease development; propose novel, contemporary and panel opinion-based diagnostic criteria and an innovative organ-based method of SOS/VOD grading classification; and review current approaches for prophylaxis and treatment of SOS/VOD. This review will hopefully illuminate pathways responsible for drug-induced liver injury and manifestations of disease, sharpen awareness of risk for disease development and enhance the timely and correct diagnosis of SOS/VOD post-HCT." @default.
- W3010121256 created "2020-03-13" @default.
- W3010121256 creator A5001697191 @default.
- W3010121256 creator A5034651124 @default.
- W3010121256 creator A5040158605 @default.
- W3010121256 creator A5042915360 @default.
- W3010121256 date "2020-03-04" @default.
- W3010121256 modified "2023-10-14" @default.
- W3010121256 title "Modified diagnostic criteria, grading classification and newly elucidated pathophysiology of hepatic SOS/VOD after haematopoietic cell transplantation" @default.
- W3010121256 cites W143372461 @default.
- W3010121256 cites W1779344217 @default.
- W3010121256 cites W1859572238 @default.
- W3010121256 cites W1965108582 @default.
- W3010121256 cites W1965779979 @default.
- W3010121256 cites W1966771497 @default.
- W3010121256 cites W1968157613 @default.
- W3010121256 cites W1969216286 @default.
- W3010121256 cites W1972172571 @default.
- W3010121256 cites W1973519172 @default.
- W3010121256 cites W1986632176 @default.
- W3010121256 cites W1986911625 @default.
- W3010121256 cites W1993605133 @default.
- W3010121256 cites W1993783426 @default.
- W3010121256 cites W199387403 @default.
- W3010121256 cites W1994417270 @default.
- W3010121256 cites W1999450971 @default.
- W3010121256 cites W2007501893 @default.
- W3010121256 cites W2010160231 @default.
- W3010121256 cites W2017821630 @default.
- W3010121256 cites W2022913214 @default.
- W3010121256 cites W2024232074 @default.
- W3010121256 cites W2025996170 @default.
- W3010121256 cites W2029173845 @default.
- W3010121256 cites W2035809865 @default.
- W3010121256 cites W2037010003 @default.
- W3010121256 cites W2044319802 @default.
- W3010121256 cites W2048818389 @default.
- W3010121256 cites W2049408553 @default.
- W3010121256 cites W2053416351 @default.
- W3010121256 cites W2059353285 @default.
- W3010121256 cites W2061293556 @default.
- W3010121256 cites W2061315540 @default.
- W3010121256 cites W2064322221 @default.
- W3010121256 cites W2065601733 @default.
- W3010121256 cites W2066216766 @default.
- W3010121256 cites W2066452515 @default.
- W3010121256 cites W2067329870 @default.
- W3010121256 cites W2074337926 @default.
- W3010121256 cites W2082582759 @default.
- W3010121256 cites W2085644837 @default.
- W3010121256 cites W2089287898 @default.
- W3010121256 cites W2090989822 @default.
- W3010121256 cites W2095124784 @default.
- W3010121256 cites W2102878999 @default.
- W3010121256 cites W2103085620 @default.
- W3010121256 cites W2121599032 @default.
- W3010121256 cites W2122652108 @default.
- W3010121256 cites W2125312770 @default.
- W3010121256 cites W2127224360 @default.
- W3010121256 cites W2132203015 @default.
- W3010121256 cites W2134138207 @default.
- W3010121256 cites W2137529567 @default.
- W3010121256 cites W2142670793 @default.
- W3010121256 cites W2146443431 @default.
- W3010121256 cites W2148164607 @default.
- W3010121256 cites W2150084215 @default.
- W3010121256 cites W2150177922 @default.
- W3010121256 cites W2150355770 @default.
- W3010121256 cites W2151348405 @default.
- W3010121256 cites W2151475548 @default.
- W3010121256 cites W2163914817 @default.
- W3010121256 cites W2164122959 @default.
- W3010121256 cites W2164779038 @default.
- W3010121256 cites W2175927969 @default.
- W3010121256 cites W2180061107 @default.
- W3010121256 cites W2295805773 @default.
- W3010121256 cites W2297989334 @default.
- W3010121256 cites W2342148351 @default.
- W3010121256 cites W2396687607 @default.
- W3010121256 cites W2418658443 @default.
- W3010121256 cites W2462936585 @default.
- W3010121256 cites W2470906679 @default.
- W3010121256 cites W2504660737 @default.
- W3010121256 cites W2604031493 @default.
- W3010121256 cites W2608455444 @default.
- W3010121256 cites W2613460655 @default.
- W3010121256 cites W2730231599 @default.
- W3010121256 cites W2776038747 @default.
- W3010121256 cites W2782257368 @default.
- W3010121256 cites W2783948359 @default.
- W3010121256 cites W2793137791 @default.
- W3010121256 cites W2803440649 @default.
- W3010121256 cites W2803655366 @default.
- W3010121256 cites W2803717642 @default.
- W3010121256 cites W2809534462 @default.
- W3010121256 cites W2885952230 @default.
- W3010121256 cites W2886906891 @default.
- W3010121256 cites W2893513865 @default.