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- W3010130906 abstract "Abstract Laryngeal squamous cell carcinoma (LSCC) responds to 17β-estradiol via estrogen-receptor (ER, transcribed from ESR1) dependent mechanisms, but is not recognized as a hormonally responsive cancer. 17β-estradiol production by LSCC cell lines UM-SCC-11A and UM-SCC-12 was examined. Wild type (WT) and ESR1-silenced LSCC cultures and xenografts were examined for 17β-estradiol responsiveness in vivo . 14 LSCC and surrounding epithelial samples at various pathological stages were obtained from patients; ERα and ERβ expression were verified using data from the total cancer genome atlas. UM-SCC-11A and UM-SCC-12 both produce 17β-estradiol, but only UM-SCC-12, not UM-SCC-11A, xenograft tumors grow larger in vivo in response to systemic 17β-estradiol treatments. ERα66 and ERα36 expression inversely correlated with clinical cancer stage and tumor burden. LSCC ERα66 expression was higher compared to surrounding epithelia in indolent samples but lower in aggressive LSCC. ERβ expression was highly variable. High ESR1 expression correlated with improved survival in LSCC. Loss of ERα66 expression inversely correlated with prognosis in LSCC. ERα66 may be a histopathological marker of aggression in LSCC." @default.
- W3010130906 created "2020-03-13" @default.
- W3010130906 creator A5014329052 @default.
- W3010130906 creator A5029880479 @default.
- W3010130906 creator A5031781193 @default.
- W3010130906 creator A5046515529 @default.
- W3010130906 creator A5049178169 @default.
- W3010130906 creator A5052368052 @default.
- W3010130906 creator A5077459124 @default.
- W3010130906 creator A5086565119 @default.
- W3010130906 date "2020-03-06" @default.
- W3010130906 modified "2023-09-25" @default.
- W3010130906 title "Loss of Estrogen Receptors is Associated with Increased Tumor Aggression in Laryngeal Squamous Cell Carcinoma" @default.
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