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- W3010138505 abstract "Previous studies identify a role for hypothalamic glia in energy balance regulation; however, a narrow hypothalamic focus provides an incomplete understanding of how glia throughout the brain respond to and regulate energy homeostasis. We examined the responses of glia in the dorsal vagal complex (DVC) to the adipokine leptin and high fat diet-induced obesity. DVC astrocytes functionally express the leptin receptor; in vivo pharmacological studies suggest that DVC astrocytes partly mediate the anorectic effects of leptin in lean but not diet-induced obese rats. Ex vivo calcium imaging indicated that these changes were related to a lower proportion of leptin-responsive cells in the DVC of obese versus lean animals. Finally, we investigated DVC microglia and astroglia responses to leptin and energy balance dysregulation in vivo: obesity decreased DVC astrogliosis, whereas the absence of leptin signaling in Zucker rats was associated with extensive astrogliosis in the DVC and decreased hypothalamic micro- and astrogliosis. These data uncover a novel functional heterogeneity of astrocytes in different brain nuclei of relevance to leptin signaling and energy balance regulation." @default.
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- W3010138505 date "2020-03-09" @default.
- W3010138505 modified "2023-09-26" @default.
- W3010138505 title "Dorsal vagal complex and hypothalamic glia differentially respond to leptin and energy balance dysregulation" @default.
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- W3010138505 cites W1981637093 @default.
- W3010138505 cites W1987097625 @default.
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- W3010138505 cites W1991146767 @default.
- W3010138505 cites W1992423721 @default.
- W3010138505 cites W1997581207 @default.
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- W3010138505 cites W2001247472 @default.
- W3010138505 cites W2004683657 @default.
- W3010138505 cites W2006244956 @default.
- W3010138505 cites W2006275533 @default.
- W3010138505 cites W2009733652 @default.
- W3010138505 cites W2018870528 @default.
- W3010138505 cites W2020138925 @default.
- W3010138505 cites W2020761570 @default.
- W3010138505 cites W2022081804 @default.
- W3010138505 cites W2023450962 @default.
- W3010138505 cites W2024023663 @default.
- W3010138505 cites W2028654736 @default.
- W3010138505 cites W2031299021 @default.
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- W3010138505 cites W2044730840 @default.
- W3010138505 cites W2049812112 @default.
- W3010138505 cites W2054966058 @default.
- W3010138505 cites W2062302492 @default.
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- W3010138505 cites W2073440229 @default.
- W3010138505 cites W2074661552 @default.
- W3010138505 cites W2075224236 @default.
- W3010138505 cites W2077335475 @default.
- W3010138505 cites W2080466389 @default.
- W3010138505 cites W2083453611 @default.
- W3010138505 cites W2083763054 @default.
- W3010138505 cites W2092554038 @default.
- W3010138505 cites W2096209210 @default.
- W3010138505 cites W2099036248 @default.
- W3010138505 cites W2109684842 @default.
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- W3010138505 cites W2116738591 @default.
- W3010138505 cites W2117691576 @default.
- W3010138505 cites W2127621191 @default.
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- W3010138505 cites W2230269655 @default.
- W3010138505 cites W2273843302 @default.
- W3010138505 cites W2280077905 @default.
- W3010138505 cites W2303718151 @default.
- W3010138505 cites W2309788064 @default.
- W3010138505 cites W2410495115 @default.
- W3010138505 cites W2465638754 @default.
- W3010138505 cites W2491903999 @default.
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- W3010138505 doi "https://doi.org/10.1038/s41398-020-0767-0" @default.
- W3010138505 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7062837" @default.
- W3010138505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32152264" @default.
- W3010138505 hasPublicationYear "2020" @default.
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