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• W3010168497 abstract "Analysis of miRNAs has a strong potential for the identification of novel prognostic or predictive biomarkers in the serum of AD patients. In this study, we investigated the serum levels of miR-106b as a diagnostic biomarker for AD and evaluate its predictive value for therapeutic response to the drug rivastigmine. Patients were divided into either responding (n = 33) or non-responding (n = 23) groups according to rivastigmine treatment and to Mini-Mental State Exam score. The serum concentrations of miR-106b were measured with real-time PCR. Here, we found that miR-106b was significantly down-regulated in the serum samples of AD patients compared with those of controls (p < .001). ROC results showed a specificity of 62% and a sensitivity of 94%. The serum values of miR-106b tended to be positively associated with the therapeutic response but were not significant (p = .15). Taken together, detection of serum miR-106b might be a promising serum biomarker for early diagnosis of AD." @default.
• W3010168497 created "2020-03-13" @default.
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• W3010168497 date "2020-03-06" @default.
• W3010168497 modified "2023-10-15" @default.
• W3010168497 title "Downregulation of serum miR-106b: a potential biomarker for Alzheimer disease" @default.
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• W3010168497 doi "https://doi.org/10.1080/13813455.2020.1734842" @default.
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