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• W3010191937 endingPage "128" @default.
• W3010191937 startingPage "122" @default.
• W3010191937 abstract "Impaired fibrinolysis as a result of increased plasminogen activator inhibitor‐1 (PAI‐1) levels in plasma is a common finding in patients with deep vein thrombosis (DVT). A 4G/5G polymorphism in the promoter region of the PAI‐1 gene has been reported to influence the levels of PAI‐1. The 4G allele was found to be associated with higher plasma PAI‐1 activity (act), but contradictory results on the incidence of the 4G allele in DVT patients have been reported. The aim of this study was to analyse whether the PAI‐1 promoter 4G/5G genotype increases the risk of venous thrombosis in subjects with thrombophilic defects, and to determine the distribution of the PAI‐1 4G/5G genotype and its relation to plasma PAI‐1 levels in 190 unrelated patients with DVT in comparison with a control group of 152 healthy subjects. No differences between the 4G/5G allele distribution in the DVT group (0·43/0·57) and in the control group (0·42/0·58) were observed. However, the presence of the 4G allele significantly increased the risk of thrombosis in patients with other thrombophilic defects. Significantly higher PAI‐1 levels were observed in DVT patients than in the controls. Our results also showed significant differences in the plasma levels of PAI‐1 antigen (ag) and PAI‐1 act among the 4G/5G genotypes in DVT patients. A multivariate analysis revealed that, in the DVT group, PAI‐1 ag levels were influenced by the 4G allele dosage, triglyceride levels and body mass index (BMI). The influence of the 4G allele dosage on PAI‐1 levels was independent of the triglyceride levels and BMI. In the control group, no significant correlation between PAI‐1 levels and 4G allele dosage was observed. In conclusion, the PAI‐1 promoter polymorphism was found to have an influence on PAI‐1 levels in DVT patients and on the risk of venous thrombosis in subjects with other genetic thrombophilic defects." @default.
• W3010191937 created "2020-03-13" @default.
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• W3010191937 date "2000-10-01" @default.
• W3010191937 modified "2023-10-18" @default.
• W3010191937 title "PAI-1 promoter 4G/5G genotype as an additional risk factor for venous thrombosis in subjects with genetic thrombophilic defects" @default.
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• W3010191937 doi "https://doi.org/10.1111/j.1365-2141.2000.02321.x" @default.
• W3010191937 hasPublicationYear "2000" @default.
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