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• W3010197422 abstract "Abstract A new bacterial strain, designated HM134 T , was isolated from a sample of soil collected from a Chinese mangrove Avicennia marina forest. Assessed by a polyphasic approach, the taxonomy of strain HM134 T was found to be associated with a range of phylogenetic and chemotaxonomic properties consistent with the genus Micromonospora . Phylogenetic analysis based on the 16s rRNA gene sequence indicated that strain HM134 T formed a distinct lineage with the most closely related species, including M . rifamycinica AM105 T , M . wenchangensis CCTCC AA 2012002 T and M. mangrovi 2803GPT1-18 T . The ANI values between strain HM134 T and the reference strains ranged from 82.6% to 95.2%, which was below the standard criteria for classifying strains as the same species (96.5%). Strain HM134 T and related species shared in silico dDDH similarities values below the recommended 70% cut-off for the delineation of species (range from 25.7–62.6%). The DNA G+C content of strain HM134 T was 73.2 mol%. Analysis of phylogenetic, genomic, phenotypic and chemotaxonomic characteristics revealed that strain HM134 T is considered to represent a novel species of the genus Micromonospora , for which the name M . zhangzhouensis sp. nov. is proposed. The extract of strain HM134 T was demonstrated to exhibit cytotoxic activity against the human cancer cell lines HepG2, HCT-116 and A549. Active substance presented in the fermentation broth of strain HM134 T was isolated by bioassay-guided analysis and purified afterwards. A new derivative of diterpenoid was identified through electrospray ionizing mass spectrometry (MS) and nuclear magnetic resonance (NMR). The compound showed different cytotoxic activities against cancer cells, with the highest cytotoxicity against HCT-116, corresponding to IC 50 value of 38.4 μg/mL." @default.
• W3010197422 created "2020-03-13" @default.
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• W3010197422 date "2020-03-03" @default.
• W3010197422 modified "2023-10-17" @default.
• W3010197422 title "Micromonospora zhangzhouensis sp. nov., a Novel Actinobacterium Isolated from Mangrove Soil, Exerts a Cytotoxic Activity in vitro" @default.
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• W3010197422 doi "https://doi.org/10.1038/s41598-020-60677-0" @default.
• W3010197422 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7054543" @default.
• W3010197422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32127574" @default.
• W3010197422 hasPublicationYear "2020" @default.
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