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• W3010198026 abstract "In order to investigate the correlation among cytokine production and antiretroviral therapy (ART), viral load, CD4 + and CD8 + T lymphocytes, 55 human immunodeficiency virus (HIV)‐1‐infected children on ART or not, and 16 uninfected controls were studied. Peripheral blood mononuclear cells (PBMCs) of HIV‐1‐infected children and controls were cultured and spontaneous and mitogen‐stimulated cytokines production was quantified in the supernatants. Viral load was quantified using standard molecular assay. CD4 and CD8 T‐lymphocyte counts were determined by flow cytometry. Cytokine production by mitogen‐stimulated PBMCs showed different profiles in HIV‐1 children whether treated or not. The tumour necrosis factor (TNF)‐α production was higher and the interleukin (IL)‐10 production was lower in the HIV‐1‐untreated group than in the HIV‐1‐treated children and controls. The IL‐2 production was reduced and the RANTES production was higher in both HIV‐1 groups compared with the controls. The interferon (IFN)‐γ and the IL‐5 production was significantly reduced in the HIV‐1‐treated children compared to the controls. Interestingly, the analysis of the correlation of HIV‐1 phenotype with cytokine production indicated an increased RANTES production in relation to nonsyncytium‐inducing viral phenotype with slow/low replication profile, whereas decreased IL‐10 levels was associated to syncytium‐inducing (SI) strains and rapid/high replication. Our findings suggest that AVT changes on the cytokine and chemokine production play an important role in the HIV pathogenesis." @default.
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• W3010198026 date "2000-12-01" @default.
• W3010198026 modified "2023-10-18" @default.
• W3010198026 title "Clinical Relevance of Cytokine Production in HIV-1 Infection in Children on Antiretroviral Therapy" @default.
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• W3010198026 doi "https://doi.org/10.1111/j.1365-3083.2000.00831.x" @default.
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