Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010240886> ?p ?o ?g. }
- W3010240886 abstract "Abstract Therapeutic normal IgG intravenous immunoglobulin (IVIG) is a well-established first-line immunotherapy for many autoimmune and inflammatory diseases. Though several mechanisms have been proposed for the anti-inflammatory actions of IVIG, associated signaling pathways are not well studied. As β-catenin, the central component of the canonical Wnt pathway, plays an important role in imparting tolerogenic properties to dendritic cells (DCs) and in reducing inflammation, we explored whether IVIG induces the β-catenin pathway to exert anti-inflammatory effects. We show that IVIG in an IgG-sialylation independent manner activates β-catenin in human DCs along with upregulation of Wnt5a secretion. Mechanistically, β-catenin activation by IVIG requires intact IgG and LRP5/6 co-receptors, but FcγRIIA and Syk are not implicated. Despite induction of β-catenin, this pathway is dispensable for anti-inflammatory actions of IVIG in vitro and for mediating the protection against experimental autoimmune encephalomyelitis in vivo in mice, and reciprocal regulation of effector Th17/Th1 and regulatory T cells." @default.
- W3010240886 created "2020-03-13" @default.
- W3010240886 creator A5008242508 @default.
- W3010240886 creator A5008256897 @default.
- W3010240886 creator A5011054557 @default.
- W3010240886 creator A5015455280 @default.
- W3010240886 creator A5024728040 @default.
- W3010240886 creator A5037652352 @default.
- W3010240886 creator A5085362965 @default.
- W3010240886 creator A5086147416 @default.
- W3010240886 creator A5089079882 @default.
- W3010240886 date "2020-03-04" @default.
- W3010240886 modified "2023-10-11" @default.
- W3010240886 title "Therapeutic normal IgG intravenous immunoglobulin activates Wnt-β-catenin pathway in dendritic cells" @default.
- W3010240886 cites W1491869942 @default.
- W3010240886 cites W1501596399 @default.
- W3010240886 cites W1548904081 @default.
- W3010240886 cites W1557312589 @default.
- W3010240886 cites W1838834699 @default.
- W3010240886 cites W1862461292 @default.
- W3010240886 cites W1906432510 @default.
- W3010240886 cites W1969344434 @default.
- W3010240886 cites W1974595623 @default.
- W3010240886 cites W1975481830 @default.
- W3010240886 cites W1977978637 @default.
- W3010240886 cites W1983712244 @default.
- W3010240886 cites W1985075809 @default.
- W3010240886 cites W1994453451 @default.
- W3010240886 cites W2006419043 @default.
- W3010240886 cites W2006521244 @default.
- W3010240886 cites W2008892281 @default.
- W3010240886 cites W2009684443 @default.
- W3010240886 cites W2011984976 @default.
- W3010240886 cites W2018834134 @default.
- W3010240886 cites W2028137697 @default.
- W3010240886 cites W2029246797 @default.
- W3010240886 cites W2029249008 @default.
- W3010240886 cites W2030130606 @default.
- W3010240886 cites W2034901554 @default.
- W3010240886 cites W2044459637 @default.
- W3010240886 cites W2057148298 @default.
- W3010240886 cites W2061460524 @default.
- W3010240886 cites W2071049906 @default.
- W3010240886 cites W2071340135 @default.
- W3010240886 cites W2071856565 @default.
- W3010240886 cites W2072335762 @default.
- W3010240886 cites W2086854604 @default.
- W3010240886 cites W2087251699 @default.
- W3010240886 cites W2089820020 @default.
- W3010240886 cites W2091948625 @default.
- W3010240886 cites W2094655231 @default.
- W3010240886 cites W2095203753 @default.
- W3010240886 cites W2095374840 @default.
- W3010240886 cites W2095503795 @default.
- W3010240886 cites W2097690601 @default.
- W3010240886 cites W2107509709 @default.
- W3010240886 cites W2115471441 @default.
- W3010240886 cites W2116661011 @default.
- W3010240886 cites W2119284420 @default.
- W3010240886 cites W2120269934 @default.
- W3010240886 cites W2121635719 @default.
- W3010240886 cites W2141267422 @default.
- W3010240886 cites W2143620061 @default.
- W3010240886 cites W2144233065 @default.
- W3010240886 cites W2156000546 @default.
- W3010240886 cites W2158021558 @default.
- W3010240886 cites W2163269741 @default.
- W3010240886 cites W2164356078 @default.
- W3010240886 cites W2164793815 @default.
- W3010240886 cites W2164890649 @default.
- W3010240886 cites W2278862336 @default.
- W3010240886 cites W2280913233 @default.
- W3010240886 cites W2540109840 @default.
- W3010240886 cites W2556012672 @default.
- W3010240886 cites W2567251402 @default.
- W3010240886 cites W2602697026 @default.
- W3010240886 cites W2609865146 @default.
- W3010240886 cites W2621361823 @default.
- W3010240886 cites W2726030955 @default.
- W3010240886 cites W2755022299 @default.
- W3010240886 cites W2762529457 @default.
- W3010240886 cites W2765358726 @default.
- W3010240886 cites W2801967759 @default.
- W3010240886 cites W2804245048 @default.
- W3010240886 cites W2892913291 @default.
- W3010240886 cites W2904012208 @default.
- W3010240886 cites W2944447207 @default.
- W3010240886 cites W2970561499 @default.
- W3010240886 cites W3002960176 @default.
- W3010240886 cites W4243493776 @default.
- W3010240886 cites W2122073896 @default.
- W3010240886 doi "https://doi.org/10.1038/s42003-020-0825-4" @default.
- W3010240886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7055225" @default.
- W3010240886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32132640" @default.
- W3010240886 hasPublicationYear "2020" @default.
- W3010240886 type Work @default.
- W3010240886 sameAs 3010240886 @default.
- W3010240886 citedByCount "9" @default.
- W3010240886 countsByYear W30102408862020 @default.
- W3010240886 countsByYear W30102408862021 @default.