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- W3010276544 abstract "Sickle cell disease (SCD) is caused by a point mutation in the β-globin gene that creates hemoglobin S (HbS). Upon deoxygenation, HbS forms long polymers that distort the shape of red blood cells, causing hemolysis and vaso-occlusion. Voxelotor inhibits HbS polymerization, the root cause of SCD complications. To view this Bench to Bedside, open or download the PDF." @default.
- W3010276544 created "2020-03-13" @default.
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- W3010276544 date "2020-03-01" @default.
- W3010276544 modified "2023-10-17" @default.
- W3010276544 title "Blocking HbS Polymerization in SCD" @default.
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- W3010276544 doi "https://doi.org/10.1016/j.cell.2020.01.019" @default.
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