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- W3010287313 abstract "β-carotene is a robust modulator of mucosal barriers, and it can amplify the immunoglobulin A (IgA) response via the retinoic acid (RA)-mediated pathway. We investigated the influence of β-carotene on intestinal barriers in layer-type cockerels. In this study, β-carotene has a positive influence on growth performance and intestinal morphology. β-carotene remarkably enhanced serum secretory immunoglobulin A (sIgA) levels, jejunal mucosal sIgA, and IgA concentrations. β-Carotene significantly enhanced mRNA expression levels of IgA, CC chemokine receptor-9 (CCR9), polymeric immunoglobulin receptor (pIgR), and retinoic acid receptor α (RARα) in the ileal tissues and pIgR in the jejunal tissues. β-Carotene improves mRNA expression of intestinal barrier-related proteins including: mucin-2 (MUC-2), zonula occludens-2 (ZO-2), occludins (OCLN), and zonula occludens-1 (ZO-1) in the ileal tissues. Moreover, β-carotene decreased the levels of Escherichia coli and elevates the levels of Lactobacillus. The results indicate that β-carotene can promote growth performance and contribute to the gradual development of intestinal barriers in Hyline Brown chicks. This study enriches our knowledge about the effects of β-carotene on intestinal barrier and highlights a theoretical basis of β-carotene application in the poultry industry." @default.
- W3010287313 created "2020-03-13" @default.
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- W3010287313 date "2020-01-01" @default.
- W3010287313 modified "2023-10-11" @default.
- W3010287313 title "Effects of supplementation with β‐carotene on the growth performance and intestinal mucosal barriers in layer‐type cockerels" @default.
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- W3010287313 doi "https://doi.org/10.1111/asj.13344" @default.
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