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- W3010304047 abstract "Micro(mi)RNA-based post-transcriptional regulatory mechanisms have been broadly implicated in the assembly and modulation of synaptic connections required to shape neural circuits, however, relatively few specific miRNAs have been identified that control synapse formation. Using a conditional transgenic toolkit for competitive inhibition of miRNA function in Drosophila, we performed an unbiased screen for novel regulators of synapse morphogenesis at the larval neuromuscular junction (NMJ). From a set of ten new validated regulators of NMJ growth, we discovered that miR-34 mutants display synaptic phenotypes and cell type-specific functions suggesting distinct downstream mechanisms in the presynaptic and postsynaptic compartments. A search for conserved downstream targets for miR-34 identified the junctional receptor CNTNAP4/Neurexin-IV (Nrx-IV) and the membrane cytoskeletal effector Adducin/Hu-li tai shao (Hts) as proteins whose synaptic expression is restricted by miR-34. Manipulation of miR-34, Nrx-IV or Hts-M function in motor neurons or muscle supports a model where presynaptic miR-34 inhibits Nrx-IV to influence active zone formation, whereas, postsynaptic miR-34 inhibits Hts to regulate the initiation of bouton formation from presynaptic terminals." @default.
- W3010304047 created "2020-03-13" @default.
- W3010304047 creator A5008324502 @default.
- W3010304047 creator A5011425842 @default.
- W3010304047 creator A5037306424 @default.
- W3010304047 creator A5039331886 @default.
- W3010304047 creator A5046721022 @default.
- W3010304047 creator A5058004344 @default.
- W3010304047 creator A5060461713 @default.
- W3010304047 creator A5067547622 @default.
- W3010304047 creator A5081272972 @default.
- W3010304047 creator A5088490952 @default.
- W3010304047 date "2020-02-27" @default.
- W3010304047 modified "2023-10-07" @default.
- W3010304047 title "The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells" @default.
- W3010304047 cites W1528687531 @default.
- W3010304047 cites W1533971869 @default.
- W3010304047 cites W1582652395 @default.
- W3010304047 cites W1584433563 @default.
- W3010304047 cites W1818286516 @default.
- W3010304047 cites W1920303762 @default.
- W3010304047 cites W1934152683 @default.
- W3010304047 cites W1941361479 @default.
- W3010304047 cites W1958284284 @default.
- W3010304047 cites W1966852386 @default.
- W3010304047 cites W1968300632 @default.
- W3010304047 cites W1970215478 @default.
- W3010304047 cites W1971371925 @default.
- W3010304047 cites W1974982857 @default.
- W3010304047 cites W1979141206 @default.
- W3010304047 cites W1979605148 @default.
- W3010304047 cites W1981434287 @default.
- W3010304047 cites W1989463976 @default.
- W3010304047 cites W1991022271 @default.
- W3010304047 cites W1992941735 @default.
- W3010304047 cites W1997149311 @default.
- W3010304047 cites W2003952411 @default.
- W3010304047 cites W2004390998 @default.
- W3010304047 cites W2005210974 @default.
- W3010304047 cites W2005984686 @default.
- W3010304047 cites W2021035407 @default.
- W3010304047 cites W2024137834 @default.
- W3010304047 cites W2025396682 @default.
- W3010304047 cites W2031075742 @default.
- W3010304047 cites W2034299131 @default.
- W3010304047 cites W2036560723 @default.
- W3010304047 cites W2036959083 @default.
- W3010304047 cites W2037701255 @default.
- W3010304047 cites W2039415806 @default.
- W3010304047 cites W2042239754 @default.
- W3010304047 cites W2044601473 @default.
- W3010304047 cites W2044836636 @default.
- W3010304047 cites W2048358400 @default.
- W3010304047 cites W2050378367 @default.
- W3010304047 cites W2050891719 @default.
- W3010304047 cites W2053718310 @default.
- W3010304047 cites W2056860707 @default.
- W3010304047 cites W2057098184 @default.
- W3010304047 cites W2057967101 @default.
- W3010304047 cites W2065638549 @default.
- W3010304047 cites W2066885873 @default.
- W3010304047 cites W2070571588 @default.
- W3010304047 cites W2078749921 @default.
- W3010304047 cites W2080488750 @default.
- W3010304047 cites W2082541370 @default.
- W3010304047 cites W2083381199 @default.
- W3010304047 cites W2091344124 @default.
- W3010304047 cites W2094098734 @default.
- W3010304047 cites W2096304780 @default.
- W3010304047 cites W2099348148 @default.
- W3010304047 cites W2104919785 @default.
- W3010304047 cites W2104994386 @default.
- W3010304047 cites W2105039688 @default.
- W3010304047 cites W2105336002 @default.
- W3010304047 cites W2108281485 @default.
- W3010304047 cites W2112192177 @default.
- W3010304047 cites W2113139359 @default.
- W3010304047 cites W2113606274 @default.
- W3010304047 cites W2117392783 @default.
- W3010304047 cites W2120456037 @default.
- W3010304047 cites W2120942245 @default.
- W3010304047 cites W2129692964 @default.
- W3010304047 cites W2137483641 @default.
- W3010304047 cites W2138664009 @default.
- W3010304047 cites W2146115263 @default.
- W3010304047 cites W2147786443 @default.
- W3010304047 cites W2148440440 @default.
- W3010304047 cites W2150106878 @default.
- W3010304047 cites W2162674813 @default.
- W3010304047 cites W2171398108 @default.
- W3010304047 cites W2202281942 @default.
- W3010304047 cites W2268790278 @default.
- W3010304047 cites W2293360927 @default.
- W3010304047 cites W2327211142 @default.
- W3010304047 cites W2395114866 @default.
- W3010304047 cites W2411648195 @default.
- W3010304047 cites W2560678530 @default.
- W3010304047 cites W2593819853 @default.
- W3010304047 cites W2600940151 @default.
- W3010304047 cites W2809973735 @default.