Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010323348> ?p ?o ?g. }
- W3010323348 endingPage "111240" @default.
- W3010323348 startingPage "111240" @default.
- W3010323348 abstract "Acetaminophen (APAP) is a widely used analgesic drug, which can cause severe liver injury after an overdose. The intracellular signaling mechanisms of APAP-induced cell death such as reactive metabolite formation, mitochondrial dysfunction and nuclear DNA fragmentation have been extensively studied. Hepatocyte necrosis releases damage-associated molecular patterns (DAMPs) which activate cytokine and chemokine formation in macrophages. These signals activate and recruit neutrophils, monocytes and other leukocytes into the liver. While this sterile inflammatory response removes necrotic cell debris and promotes tissue repair, the capability of leukocytes to also cause tissue injury makes this a controversial topic. This review summarizes the literature on the role of various DAMPs, cytokines and chemokines, and the pathophysiological function of Kupffer cells, neutrophils, monocytes and monocyte-derived macrophages, and NK and NKT cells during APAP hepatotoxicity. Careful evaluation of results and experimental designs of studies dealing with the inflammatory response after APAP toxicity provide very limited evidence for aggravation of liver injury but support of the hypothesis that these leukocytes promote tissue repair. In addition, many cytokines and chemokines modulate tissue injury by affecting the intracellular signaling events of cell death rather than toxicity of leukocytes. Reasons for the controversial results in this area are also discussed." @default.
- W3010323348 created "2020-03-13" @default.
- W3010323348 creator A5073983381 @default.
- W3010323348 creator A5087156903 @default.
- W3010323348 date "2020-04-01" @default.
- W3010323348 modified "2023-10-17" @default.
- W3010323348 title "Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity" @default.
- W3010323348 cites W1537971445 @default.
- W3010323348 cites W1574945736 @default.
- W3010323348 cites W1592028829 @default.
- W3010323348 cites W1614484620 @default.
- W3010323348 cites W1615432648 @default.
- W3010323348 cites W1615683666 @default.
- W3010323348 cites W168035116 @default.
- W3010323348 cites W1837277815 @default.
- W3010323348 cites W1925097974 @default.
- W3010323348 cites W1947736182 @default.
- W3010323348 cites W1953009759 @default.
- W3010323348 cites W1953460679 @default.
- W3010323348 cites W1956939601 @default.
- W3010323348 cites W1969981758 @default.
- W3010323348 cites W1971313680 @default.
- W3010323348 cites W1972310964 @default.
- W3010323348 cites W1973441276 @default.
- W3010323348 cites W1975892042 @default.
- W3010323348 cites W1981279226 @default.
- W3010323348 cites W1982664967 @default.
- W3010323348 cites W1985041654 @default.
- W3010323348 cites W1985372616 @default.
- W3010323348 cites W1987455998 @default.
- W3010323348 cites W1989422775 @default.
- W3010323348 cites W1994190235 @default.
- W3010323348 cites W1994378435 @default.
- W3010323348 cites W1997878364 @default.
- W3010323348 cites W1998748239 @default.
- W3010323348 cites W2003423132 @default.
- W3010323348 cites W2003873847 @default.
- W3010323348 cites W2003921075 @default.
- W3010323348 cites W2004266769 @default.
- W3010323348 cites W2004650652 @default.
- W3010323348 cites W2005629850 @default.
- W3010323348 cites W2006286083 @default.
- W3010323348 cites W2007456787 @default.
- W3010323348 cites W2009162867 @default.
- W3010323348 cites W2009523307 @default.
- W3010323348 cites W2009609856 @default.
- W3010323348 cites W2014325254 @default.
- W3010323348 cites W2018989049 @default.
- W3010323348 cites W2020102890 @default.
- W3010323348 cites W2021032684 @default.
- W3010323348 cites W2026694037 @default.
- W3010323348 cites W2031381742 @default.
- W3010323348 cites W2031679095 @default.
- W3010323348 cites W2033635345 @default.
- W3010323348 cites W2034692102 @default.
- W3010323348 cites W2035315634 @default.
- W3010323348 cites W2037455183 @default.
- W3010323348 cites W2040027128 @default.
- W3010323348 cites W2040558033 @default.
- W3010323348 cites W2043492787 @default.
- W3010323348 cites W2049005434 @default.
- W3010323348 cites W2053620238 @default.
- W3010323348 cites W2055525658 @default.
- W3010323348 cites W2056309362 @default.
- W3010323348 cites W2057368742 @default.
- W3010323348 cites W2059655597 @default.
- W3010323348 cites W2070436610 @default.
- W3010323348 cites W2071276803 @default.
- W3010323348 cites W2073010239 @default.
- W3010323348 cites W2074966179 @default.
- W3010323348 cites W2075675685 @default.
- W3010323348 cites W2076196872 @default.
- W3010323348 cites W2076372222 @default.
- W3010323348 cites W2076620022 @default.
- W3010323348 cites W2078036072 @default.
- W3010323348 cites W2079326842 @default.
- W3010323348 cites W2079350327 @default.
- W3010323348 cites W2083976597 @default.
- W3010323348 cites W2084540950 @default.
- W3010323348 cites W2085718426 @default.
- W3010323348 cites W2086709875 @default.
- W3010323348 cites W2086714780 @default.
- W3010323348 cites W2087996623 @default.
- W3010323348 cites W2089400257 @default.
- W3010323348 cites W2090546037 @default.
- W3010323348 cites W2092946161 @default.
- W3010323348 cites W2094129884 @default.
- W3010323348 cites W2094878778 @default.
- W3010323348 cites W2095511125 @default.
- W3010323348 cites W2097901599 @default.
- W3010323348 cites W2100903885 @default.
- W3010323348 cites W2102641420 @default.
- W3010323348 cites W2102834219 @default.
- W3010323348 cites W2104614292 @default.
- W3010323348 cites W2108218187 @default.
- W3010323348 cites W2111550054 @default.
- W3010323348 cites W2115975389 @default.
- W3010323348 cites W2117807235 @default.