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• W3010325168 abstract "After the recognition in December 2019 of a cluster of patients with pneumonia of unknown cause in Wuhan caused by the novel coronavirus, CoV-19,1 China and the world have faced the extraordinary challenge of a previously unrecognized viral illness with high infectivity.2 Every year, millions of persons (5%-15% of the world's population) contract influenza,3, 4 causing between 300 000 and 600 000 excess respiratory deaths.5 In China alone, recent estimates put the annual influenza-associated mortality rate at more than 88 000 persons,6 likely in excess of any potential outcome of coronavirus disease 2019 (COVID-19). Regardless of the potential for spread of COVID-19, as with influenza-related mortality,7 diabetes is an important risk factor for adverse outcome. Mortality rates among persons with diabetes in Hong Kong age 75 and over from pneumonia currently exceed mortality rates in this age group from cardiovascular disease and from cancer.8 Similar evidence of risk among persons with diabetes has been reported for the two earlier CoV infections, severe acute respiratory syndrome (SARS) beginning in 2002 and affecting more than 8000 persons, mainly in Asia9, 10 and the Middle East respiratory syndrome (MERS) in 2012 affecting more than 2000 persons, mainly in Saudi Arabia.11 As MERS-CoV binds to the receptor-binding domain of human dipeptidyl peptidase IV (DPP-IV), a transgenic mouse model expressing this DPP-IV receptor on pulmonary alveolar cells has been used to study the effect of diabetes in worsening disease severity, showing an association of diabetes with greater weight loss and greater pulmonary inflammation, with macrophage infiltrates similar to those seen clinically in the disease.12 We acknowledge the frontline medical staff working day and night in China to rescue critical cases and protect the public health. We know that these great efforts are now and will be in the future crucial in overcoming COVID-19. Providing care to people with diabetes is an important part of the effort. The Journal of Diabetes was started more than a decade ago in a spirit of collaboration between East and West addressing the epidemiology, etiology, pathogenesis, management, complications, and prevention of diabetes. The journal is issuing a call for submission of commentaries, original articles, and case reports regarding issues with COVID-19 in patients with diabetes, as well as descriptions of basic aspects of the interrelationships between diabetes and the novel CoV. We hope in this way to support the thousands of Chinese medical workers involving themselves in the care of patients with COVID-19, and we look forward to these efforts helping our goal of eradication of the disease. 从2019年12月在武汉发现一群由新型冠状病毒CoV-19引起的不明原因肺炎患者后, 中国乃至世界都面临着一种前所未见的高传染性病毒的挑战。每年都有数百万人(占世界人口的5%-15%)感染流感, 导致30万至60万人因呼吸系统疾病的额外死亡(excess respiratory deaths)。仅在中国, 最近估计每年与流感相关的死亡超过8.8万人, 很可能超过2019年冠状病毒病(COVID-19)所造成的潜在结果。不论COVID-19传播的潜在性如何, 它就像流感相关死亡一样, 糖尿病是其不良结果的一个重要风险因素。在香港, 75岁及以上糖尿病患者因肺炎而死亡的比率, 目前已超过这个年龄组别的心血管疾病和癌症死亡率。早些时候的两种冠状病毒感染在糖尿病患者中也报告了类似的风险证据:2002年初主要在亚洲的严重急性呼吸综合征(SARS), 它影响了8000多人；2012主要在沙特阿拉伯的中东呼吸综合征(MERS), 影响了2000多人。由于MERS-CoV可以与人二肽基肽酶IV(DPP-IV)的受体结合域结合, 利用在肺泡细胞上表达该DPP-IV受体的转基因小鼠模型研究糖尿病在疾病恶化中的作用, 结果显示糖尿病与体重减轻和更严重的肺部炎症有关, 并且可以看到和临床上相似的巨噬细胞浸润表现。 我们感谢一线医务工作者日以继夜的工作来拯救危重患者以及守护公众健康。我们知道这些努力在现在和将来都对战胜COVID-19至关重要。而为糖尿病患者提供相应治疗和护理也是这些努力中重要的一部分。《Journal of Diabetes》创刊于十多年前, 本着东西方合作的精神, 致力于研究糖尿病的流行病学、病因、发病机制、管理、并发症和预防。杂志呼吁读者投稿关于糖尿病患者感染COVID-19问题的评论、原创文章和病例报告, 以及对糖尿病和新型冠状病毒之间基本相互关系的描述。我们希望通过这种方式支持投身于COVID-19患者的治疗和护理中成千上万的中国医务工作者, 我们也期待着这些努力有助于我们实现根除这种疾病的目标。" @default.
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• W3010325168 date "2020-03-11" @default.
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• W3010325168 title "Diabetes and COVID‐19" @default.
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• W3010325168 doi "https://doi.org/10.1111/1753-0407.13027" @default.
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