FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010332034> ?p ?o ?g. }

• W3010332034 endingPage "559" @default.
• W3010332034 startingPage "559" @default.
• W3010332034 abstract "Epigenetic regulation plays an important role in the development and progression of nasopharyngeal carcinoma (NPC), but the epigenetic mechanisms underlying NPC metastasis remain poorly understood. Here, we demonstrate that hypermethylation of the UCHL1 promoter leads to its downregulation in NPC. Restoration of UCHL1 inhibited the migration and invasion of NPC cells in vitro and in vivo, and knockdown of UCHL1 promoted NPC cell migration and invasion in vitro and in vivo. Importantly, we found that UCHL1 interacts with CTTN, and may function as a ligase promoting CTTN degradation by increasing K48-linked ubiquitination of CTTN. Additionally, restoration of CTTN in NPC cells that overexpressed UCHL1 rescued UCHL1 suppressive effects on NPC cell migration and invasion, which indicated that CTTN is a functional target of UCHL1 in NPC. Our findings revealed that UCHL1 acts as a tumor suppressor gene in NPC and thus provided a novel therapeutic target for NPC treatment." @default.
• W3010332034 created "2020-03-13" @default.
• W3010332034 creator A5010712606 @default.
• W3010332034 creator A5014680510 @default.
• W3010332034 creator A5015104407 @default.
• W3010332034 creator A5020819058 @default.
• W3010332034 creator A5023328066 @default.
• W3010332034 creator A5029299515 @default.
• W3010332034 creator A5045545412 @default.
• W3010332034 creator A5046214153 @default.
• W3010332034 creator A5048287146 @default.
• W3010332034 creator A5054603016 @default.
• W3010332034 creator A5058333204 @default.
• W3010332034 creator A5065729637 @default.
• W3010332034 creator A5068036067 @default.
• W3010332034 creator A5079590603 @default.
• W3010332034 creator A5080286653 @default.
• W3010332034 creator A5091520540 @default.
• W3010332034 date "2020-02-27" @default.
• W3010332034 modified "2023-10-12" @default.
• W3010332034 title "Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN)" @default.
• W3010332034 cites W1976041483 @default.
• W3010332034 cites W1993077125 @default.
• W3010332034 cites W2009582035 @default.
• W3010332034 cites W2018393684 @default.
• W3010332034 cites W2020675312 @default.
• W3010332034 cites W2026607364 @default.
• W3010332034 cites W2041964828 @default.
• W3010332034 cites W2042303797 @default.
• W3010332034 cites W2056830859 @default.
• W3010332034 cites W2057527139 @default.
• W3010332034 cites W2059531568 @default.
• W3010332034 cites W2067750483 @default.
• W3010332034 cites W2088724822 @default.
• W3010332034 cites W2096600031 @default.
• W3010332034 cites W2101362932 @default.
• W3010332034 cites W2122209825 @default.
• W3010332034 cites W2128007030 @default.
• W3010332034 cites W2131041787 @default.
• W3010332034 cites W2154561072 @default.
• W3010332034 cites W2162075350 @default.
• W3010332034 cites W2165256106 @default.
• W3010332034 cites W2324328780 @default.
• W3010332034 cites W2469270620 @default.
• W3010332034 cites W2530977520 @default.
• W3010332034 cites W2585487460 @default.
• W3010332034 cites W2769759747 @default.
• W3010332034 cites W2773048783 @default.
• W3010332034 cites W2888066918 @default.
• W3010332034 cites W2889646458 @default.
• W3010332034 cites W2893365638 @default.
• W3010332034 cites W2906384898 @default.
• W3010332034 cites W2962733257 @default.
• W3010332034 cites W3003319481 @default.
• W3010332034 cites W4210983491 @default.
• W3010332034 doi "https://doi.org/10.3390/cells9030559" @default.
• W3010332034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7140450" @default.
• W3010332034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32120844" @default.
• W3010332034 hasPublicationYear "2020" @default.
• W3010332034 type Work @default.
• W3010332034 sameAs 3010332034 @default.
• W3010332034 citedByCount "14" @default.
• W3010332034 countsByYear W30103320342020 @default.
• W3010332034 countsByYear W30103320342021 @default.
• W3010332034 countsByYear W30103320342022 @default.
• W3010332034 countsByYear W30103320342023 @default.
• W3010332034 crossrefType "journal-article" @default.
• W3010332034 hasAuthorship W3010332034A5010712606 @default.
• W3010332034 hasAuthorship W3010332034A5014680510 @default.
• W3010332034 hasAuthorship W3010332034A5015104407 @default.
• W3010332034 hasAuthorship W3010332034A5020819058 @default.
• W3010332034 hasAuthorship W3010332034A5023328066 @default.
• W3010332034 hasAuthorship W3010332034A5029299515 @default.
• W3010332034 hasAuthorship W3010332034A5045545412 @default.
• W3010332034 hasAuthorship W3010332034A5046214153 @default.
• W3010332034 hasAuthorship W3010332034A5048287146 @default.
• W3010332034 hasAuthorship W3010332034A5054603016 @default.
• W3010332034 hasAuthorship W3010332034A5058333204 @default.
• W3010332034 hasAuthorship W3010332034A5065729637 @default.
• W3010332034 hasAuthorship W3010332034A5068036067 @default.
• W3010332034 hasAuthorship W3010332034A5079590603 @default.
• W3010332034 hasAuthorship W3010332034A5080286653 @default.
• W3010332034 hasAuthorship W3010332034A5091520540 @default.
• W3010332034 hasBestOaLocation W30103320341 @default.
• W3010332034 hasConcept C104317684 @default.
• W3010332034 hasConcept C121608353 @default.
• W3010332034 hasConcept C126322002 @default.
• W3010332034 hasConcept C134459356 @default.
• W3010332034 hasConcept C142669718 @default.
• W3010332034 hasConcept C1491633281 @default.
• W3010332034 hasConcept C173396325 @default.
• W3010332034 hasConcept C207001950 @default.
• W3010332034 hasConcept C25602115 @default.
• W3010332034 hasConcept C2776000893 @default.
• W3010332034 hasConcept C2778997737 @default.
• W3010332034 hasConcept C2779013556 @default.
• W3010332034 hasConcept C41091548 @default.
• W3010332034 hasConcept C502942594 @default.

• next