FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010341671> ?p ?o ?g. }

• W3010341671 endingPage "110044" @default.
• W3010341671 startingPage "110044" @default.
• W3010341671 abstract "The activation of microglia and inflammatory responses is essential for the process of intracerebral hemorrhage (ICH)-induced secondary brain injury (SBI). In this study, we investigated the effects of luteolin on ICH-induced SBI and the potential mechanisms. Autologous blood was injected to establish the ICH model in vivo, and oxyhemoglobin (OxyHb) was used to mimic the ICH model in vitro. We found that the administration of luteolin significantly improved motor and sensory impairments and inhibited neuronal cell degeneration in vivo. In the in vitro study, the decrease of the neuronal cell viability induced by activated microglia was alleviated by luteolin treatment. Furthermore, by antagonizing the activation of the Toll-like receptor 4 (TLR4)/TNF receptor-associated factor 6 (TRAF6)/nuclear transcription factor-κB (NF-κB) signaling pathway, the ICH-induced elevation of cytokine release was decreased after treatment with luteolin, which was confirmed both in vivo and in vitro. Additionally, we found that luteolin engaged with TRAF6 and inhibited the ubiquitination of TRAF6. Taken together, our findings demonstrate the neuroprotective effects of luteolin after ICH and the potential mechanisms, which suggest that luteolin is a potential therapeutic candidate for ICH treatment." @default.
• W3010341671 created "2020-03-13" @default.
• W3010341671 creator A5018516855 @default.
• W3010341671 creator A5026660885 @default.
• W3010341671 creator A5031625880 @default.
• W3010341671 creator A5041993686 @default.
• W3010341671 creator A5045067652 @default.
• W3010341671 creator A5051149614 @default.
• W3010341671 creator A5053571869 @default.
• W3010341671 creator A5054989646 @default.
• W3010341671 creator A5055158271 @default.
• W3010341671 creator A5071422456 @default.
• W3010341671 creator A5071677879 @default.
• W3010341671 creator A5072809229 @default.
• W3010341671 creator A5075640940 @default.
• W3010341671 creator A5079524437 @default.
• W3010341671 date "2020-06-01" @default.
• W3010341671 modified "2023-10-12" @default.
• W3010341671 title "Luteolin alleviates neuroinflammation via downregulating the TLR4/TRAF6/NF-κB pathway after intracerebral hemorrhage" @default.
• W3010341671 cites W1956809569 @default.
• W3010341671 cites W2001244796 @default.
• W3010341671 cites W2004872316 @default.
• W3010341671 cites W2032345138 @default.
• W3010341671 cites W2033963984 @default.
• W3010341671 cites W2039411981 @default.
• W3010341671 cites W2085350376 @default.
• W3010341671 cites W2108908615 @default.
• W3010341671 cites W2118695506 @default.
• W3010341671 cites W2123301364 @default.
• W3010341671 cites W2136587148 @default.
• W3010341671 cites W2141102146 @default.
• W3010341671 cites W2150105859 @default.
• W3010341671 cites W2156033447 @default.
• W3010341671 cites W2230590769 @default.
• W3010341671 cites W2284438769 @default.
• W3010341671 cites W2440474512 @default.
• W3010341671 cites W2520327637 @default.
• W3010341671 cites W2527645962 @default.
• W3010341671 cites W2562957617 @default.
• W3010341671 cites W2563826388 @default.
• W3010341671 cites W2565330593 @default.
• W3010341671 cites W2578652655 @default.
• W3010341671 cites W2591115003 @default.
• W3010341671 cites W2591328463 @default.
• W3010341671 cites W2604849278 @default.
• W3010341671 cites W2615026797 @default.
• W3010341671 cites W2625710117 @default.
• W3010341671 cites W2743743412 @default.
• W3010341671 cites W2749161078 @default.
• W3010341671 cites W2770711820 @default.
• W3010341671 cites W2775366010 @default.
• W3010341671 cites W2782432725 @default.
• W3010341671 cites W2790573072 @default.
• W3010341671 cites W2794306868 @default.
• W3010341671 cites W2797273514 @default.
• W3010341671 cites W2804492778 @default.
• W3010341671 cites W2805158663 @default.
• W3010341671 cites W2809372040 @default.
• W3010341671 cites W2883806546 @default.
• W3010341671 cites W2887139664 @default.
• W3010341671 cites W2889351028 @default.
• W3010341671 cites W2890456845 @default.
• W3010341671 cites W2895365941 @default.
• W3010341671 cites W2902118901 @default.
• W3010341671 cites W2902808986 @default.
• W3010341671 cites W2903087529 @default.
• W3010341671 cites W2903534860 @default.
• W3010341671 cites W2917968580 @default.
• W3010341671 cites W2924961853 @default.
• W3010341671 cites W2931298055 @default.
• W3010341671 cites W2935926710 @default.
• W3010341671 cites W2936324413 @default.
• W3010341671 cites W2939435099 @default.
• W3010341671 cites W2942765963 @default.
• W3010341671 cites W2944010700 @default.
• W3010341671 cites W2944682402 @default.
• W3010341671 cites W2946580072 @default.
• W3010341671 cites W2946729668 @default.
• W3010341671 cites W2947090542 @default.
• W3010341671 cites W2951717035 @default.
• W3010341671 doi "https://doi.org/10.1016/j.biopha.2020.110044" @default.
• W3010341671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32114357" @default.
• W3010341671 hasPublicationYear "2020" @default.
• W3010341671 type Work @default.
• W3010341671 sameAs 3010341671 @default.
• W3010341671 citedByCount "34" @default.
• W3010341671 countsByYear W30103416712020 @default.
• W3010341671 countsByYear W30103416712021 @default.
• W3010341671 countsByYear W30103416712022 @default.
• W3010341671 countsByYear W30103416712023 @default.
• W3010341671 crossrefType "journal-article" @default.
• W3010341671 hasAuthorship W3010341671A5018516855 @default.
• W3010341671 hasAuthorship W3010341671A5026660885 @default.
• W3010341671 hasAuthorship W3010341671A5031625880 @default.
• W3010341671 hasAuthorship W3010341671A5041993686 @default.
• W3010341671 hasAuthorship W3010341671A5045067652 @default.
• W3010341671 hasAuthorship W3010341671A5051149614 @default.
• W3010341671 hasAuthorship W3010341671A5053571869 @default.

• next