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• W3010353043 abstract "La bronchopneumopathie chronique obstructive (BPCO) est une atteinte chronique des voies aériennes distales caractérisée par une destruction irréversible des bronchioles terminales. Bien que les mécanismes physiopathologiques demeurent incompris à ce jour, l’épithélium bronchique semble être le chef d’orchestre de la maladie. De récentes études ont montré l’existence de différentes trajectoires de la maladie incluant dans la moitié des cas une origine pédiatrique. La modélisation de la BPCO constitue donc un enjeu majeur mais les modèles actuels sont imparfaits. La différenciation des cellules souches pluripotentes induites humaines (hiPSC) en épithélium bronchique représente un nouvel outil pour étudier les racines pédiatriques de la maladie et identifier de nouvelles cibles thérapeutiques. Chronic obstructive pulmonary disease (COPD) is a chronic lung disease leading to irreversible destruction of the terminal bronchioles. Although the precise patho-physiological mechanisms remain to be elucidated, the bronchial epithelium seems to play a pivotal role in the disease. Recent studies have highlighted a great heterogeneity among COPD patients, with various disease courses including, in about half the cases, an origin in childhood. Modelling of COPD is a major goal but currently available models are imperfect. Our work aims to create a new in vitro cellular model to study the pathology of the disease. The differentiation of human induced pluripotential stem cells (hiPSCs) in bronchial epithelium is a step towards a better understanding of the developmental origin and the identification of new therapeutic targets." @default.
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• W3010353043 date "2020-03-01" @default.
• W3010353043 modified "2023-10-04" @default.
• W3010353043 title "Modélisation de l’épithélium bronchique dans la bronchopneumopathie chronique obstructive par les cellules souches pluripotentes induites humaines" @default.
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• W3010353043 doi "https://doi.org/10.1016/j.rmr.2020.02.003" @default.
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