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- W3010407583 abstract "Abstract The development of a small library of 4-anilinoquinolines led to the identification of 7-iodo- N -(3,4,5-trimethoxyphenyl)quinolin-4-amine 16 as a potent inhibitor of Protein Kinase Novel 3 (PKN3) with an IC 50 of 1.3 μM in cells. Compound 16 presents a useful potential tool compound to study the biology of PKN3 including links to pancreatic and prostate cancer, along with T-cell acute lymphoblastic leukemia. These compounds may be useful tools to explore the therapeutic potential of PKN3 inhibition in prevention of a broad range of infectious and systemic diseases." @default.
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- W3010407583 date "2020-03-03" @default.
- W3010407583 modified "2023-09-23" @default.
- W3010407583 title "Identification and Optimization of cell active 4-anilino-quin(az)oline Inhibitors for Protein Kinase Novel 3 (PKN3)" @default.
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- W3010407583 doi "https://doi.org/10.1101/2020.03.02.972943" @default.
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