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- W3010409334 abstract "While the major function of transfer RNA is conserved across the tree of life, organisms differ in the tRNA genes that they carry. Here, we provide insight into the mechanisms by which bacterial tRNA gene sets evolve. We use mathematical modelling to demonstrate that while rapid translation generally promotes the elimination of non-essential tRNA types, there are conditions under which retention is predicted. We test our predictions by eliminating non-essential tRNA-Ser(CGA) from Pseudomonas fluorescens SBW25, generating a conditional growth defect that is rapidly compensated during an evolution experiment. Compensation occurs through large scale, tandem duplication events encompassing the gene encoding tRNA-Ser(UGA). Each genetic duplication is accompanied by a two fold increase in mature tRNA-Ser(UGA). We revisit our models to demonstrate how eliminating tRNA-Ser(CGA) and subsequently increasing tRNA Ser(UGA) can decrease and then elevate translation speed. Together, our results reveal spontaneous gene duplication as a novel mechanism of bacterial tRNA gene set evolution." @default.
- W3010409334 created "2020-03-13" @default.
- W3010409334 creator A5024312279 @default.
- W3010409334 creator A5069829871 @default.
- W3010409334 creator A5081284651 @default.
- W3010409334 date "2020-04-15" @default.
- W3010409334 modified "2023-09-23" @default.
- W3010409334 title "The birth of a bacterial tRNA gene" @default.
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- W3010409334 hasPublicationYear "2020" @default.
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