Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010409969> ?p ?o ?g. }
- W3010409969 abstract "Mycobacterium tuberculosis infection causes high rates of morbidity and mortality. Host-directed therapy may enhance the immune response, reduce tissue damage and shorten treatment duration. The inflammasome is integral to innate immune responses but over-activation has been described in tuberculosis (TB) pathology and TB-immune reconstitution syndrome. Here we explore how clinical isolates differentially activate the inflammasome and how inflammasome inhibition can lead to enhanced bacterial clearance. Wild-type, Nlrp3-/-/Aim2-/-, Casp1/11-/- and Asc-/- murine bone-marrow derived macrophages (BMDMs) were infected with laboratory strain M. tuberculosis H37Rv or clinical isolates from various lineages. Inflammasome activation and bacterial numbers were measured, and pharmacological inhibition of NLRP3 was achieved using MCC950. Clinical isolates of M. tuberculosis differed in their ability to activate inflammasomes. Beijing isolates had contrasting effects on IL-1β and caspase-1 activation, but all clinical isolates induced lower IL-1β release than H37Rv. Our studies suggest the involvement of NLRP3, AIM2 and an additional unknown sensor in IL-1β maturation. Pharmacological blockade of NLRP3 with MCC950 reduced bacterial survival, and combined treatment with the antimycobacterial drug rifampicin enhanced the effect. Modulating the inflammasome is an attractive adjunct to current anti-mycobacterial therapy that warrants further investigation." @default.
- W3010409969 created "2020-03-13" @default.
- W3010409969 creator A5017940487 @default.
- W3010409969 creator A5029944065 @default.
- W3010409969 creator A5030580990 @default.
- W3010409969 creator A5073332092 @default.
- W3010409969 date "2020-02-28" @default.
- W3010409969 modified "2023-10-14" @default.
- W3010409969 title "Genetic and pharmacological inhibition of inflammasomes reduces the survival of Mycobacterium tuberculosis strains in macrophages" @default.
- W3010409969 cites W1574328698 @default.
- W3010409969 cites W1842857806 @default.
- W3010409969 cites W1850274897 @default.
- W3010409969 cites W1963954472 @default.
- W3010409969 cites W1975032025 @default.
- W3010409969 cites W1975145629 @default.
- W3010409969 cites W1987681862 @default.
- W3010409969 cites W1989249407 @default.
- W3010409969 cites W2004815652 @default.
- W3010409969 cites W2007432455 @default.
- W3010409969 cites W2011075236 @default.
- W3010409969 cites W2020767338 @default.
- W3010409969 cites W2030623047 @default.
- W3010409969 cites W2045776845 @default.
- W3010409969 cites W2048884877 @default.
- W3010409969 cites W2072680575 @default.
- W3010409969 cites W2081244074 @default.
- W3010409969 cites W2083889567 @default.
- W3010409969 cites W2092523176 @default.
- W3010409969 cites W2093627406 @default.
- W3010409969 cites W2105296171 @default.
- W3010409969 cites W2105789139 @default.
- W3010409969 cites W2111397679 @default.
- W3010409969 cites W2116128143 @default.
- W3010409969 cites W2118749559 @default.
- W3010409969 cites W2120815988 @default.
- W3010409969 cites W2122611554 @default.
- W3010409969 cites W2126595814 @default.
- W3010409969 cites W2127119945 @default.
- W3010409969 cites W2140637559 @default.
- W3010409969 cites W2148657042 @default.
- W3010409969 cites W2156298917 @default.
- W3010409969 cites W2158758822 @default.
- W3010409969 cites W2165892953 @default.
- W3010409969 cites W2270865811 @default.
- W3010409969 cites W2337949768 @default.
- W3010409969 cites W2419297424 @default.
- W3010409969 cites W2468673773 @default.
- W3010409969 cites W2508156341 @default.
- W3010409969 cites W2522054313 @default.
- W3010409969 cites W2538911713 @default.
- W3010409969 cites W2548884024 @default.
- W3010409969 cites W2734949631 @default.
- W3010409969 cites W2788443790 @default.
- W3010409969 cites W2800885808 @default.
- W3010409969 cites W2803163846 @default.
- W3010409969 cites W2925159988 @default.
- W3010409969 cites W304241285 @default.
- W3010409969 cites W4249622281 @default.
- W3010409969 cites W4385997046 @default.
- W3010409969 doi "https://doi.org/10.1038/s41598-020-60560-y" @default.
- W3010409969 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7048741" @default.
- W3010409969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32111888" @default.
- W3010409969 hasPublicationYear "2020" @default.
- W3010409969 type Work @default.
- W3010409969 sameAs 3010409969 @default.
- W3010409969 citedByCount "15" @default.
- W3010409969 countsByYear W30104099692020 @default.
- W3010409969 countsByYear W30104099692021 @default.
- W3010409969 countsByYear W30104099692022 @default.
- W3010409969 countsByYear W30104099692023 @default.
- W3010409969 crossrefType "journal-article" @default.
- W3010409969 hasAuthorship W3010409969A5017940487 @default.
- W3010409969 hasAuthorship W3010409969A5029944065 @default.
- W3010409969 hasAuthorship W3010409969A5030580990 @default.
- W3010409969 hasAuthorship W3010409969A5073332092 @default.
- W3010409969 hasBestOaLocation W30104099691 @default.
- W3010409969 hasConcept C136449434 @default.
- W3010409969 hasConcept C139964883 @default.
- W3010409969 hasConcept C142724271 @default.
- W3010409969 hasConcept C187831198 @default.
- W3010409969 hasConcept C203014093 @default.
- W3010409969 hasConcept C2776914184 @default.
- W3010409969 hasConcept C2777209026 @default.
- W3010409969 hasConcept C2777975735 @default.
- W3010409969 hasConcept C2779685592 @default.
- W3010409969 hasConcept C2781069245 @default.
- W3010409969 hasConcept C71924100 @default.
- W3010409969 hasConcept C86803240 @default.
- W3010409969 hasConcept C8891405 @default.
- W3010409969 hasConcept C89423630 @default.
- W3010409969 hasConceptScore W3010409969C136449434 @default.
- W3010409969 hasConceptScore W3010409969C139964883 @default.
- W3010409969 hasConceptScore W3010409969C142724271 @default.
- W3010409969 hasConceptScore W3010409969C187831198 @default.
- W3010409969 hasConceptScore W3010409969C203014093 @default.
- W3010409969 hasConceptScore W3010409969C2776914184 @default.
- W3010409969 hasConceptScore W3010409969C2777209026 @default.
- W3010409969 hasConceptScore W3010409969C2777975735 @default.
- W3010409969 hasConceptScore W3010409969C2779685592 @default.
- W3010409969 hasConceptScore W3010409969C2781069245 @default.