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- W3010410249 abstract "Distal appendages (DAs) of the mother centriole are essential for the initial steps of ciliogenesis in G1/G0 phase of the cell cycle. DAs are released from centrosomes in mitosis by an undefined mechanism. Here, we show that specific DAs lose their centrosomal localization at the G2/M transition in a manner that relies upon Nek2 kinase activity to ensure low DA levels at mitotic centrosomes. Overexpression of active Nek2A, but not kinase-dead Nek2A, prematurely displaced DAs from the interphase centrosomes of immortalized retina pigment epithelial (RPE1) cells. This dramatic impact was also observed in mammary epithelial cells with constitutively high levels of Nek2. Conversely, Nek2 knockout led to incomplete dissociation of DAs and cilia in mitosis. As a consequence, we observed the presence of a cilia remnant that promoted the asymmetric inheritance of ciliary signaling components and supported cilium reassembly after cell division. Together, our data establish Nek2 as an important kinase that regulates DAs before mitosis." @default.
- W3010410249 created "2020-03-13" @default.
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- W3010410249 date "2020-02-14" @default.
- W3010410249 modified "2023-10-15" @default.
- W3010410249 title "Nek2 kinase displaces distal appendages from the mother centriole prior to mitosis" @default.
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- W3010410249 doi "https://doi.org/10.1083/jcb.201907136" @default.
- W3010410249 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7055001" @default.
- W3010410249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32211891" @default.
- W3010410249 hasPublicationYear "2020" @default.
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