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- W3010426329 abstract "Abstract Co-inhibitory pathways have a fundamental function in regulating T cell responses and control the balance between promoting efficient effector functions and restricting immune pathology. The TIGIT pathway has been implicated in promoting T cell dysfunction in chronic viral infection. Importantly, TIGIT signaling is functionally linked to IL-10 expression, which has an effect on both virus control and maintenance of tissue homeostasis. However, whether TIGIT has a function in viral persistence or limiting tissue pathology is unclear. Here we report that TIGIT modulation effectively alters the phenotype and cytokine profile of T cells during influenza and chronic LCMV infection, but does not affect virus control in vivo. Instead, TIGIT has an important effect in limiting immune pathology in peripheral organs by inducing IL-10. Our data therefore identify a function of TIGIT in limiting immune pathology that is independent of viral clearance." @default.
- W3010426329 created "2020-03-13" @default.
- W3010426329 creator A5008537578 @default.
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- W3010426329 date "2020-03-09" @default.
- W3010426329 modified "2023-09-30" @default.
- W3010426329 title "TIGIT limits immune pathology during viral infections" @default.
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- W3010426329 doi "https://doi.org/10.1038/s41467-020-15025-1" @default.
- W3010426329 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7062903" @default.
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