Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010441512> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3010441512 endingPage "6" @default.
- W3010441512 startingPage "6" @default.
- W3010441512 abstract "Hippocampus plays a pivotal role in learning and memory formation. Subgranular zone of the dentate gyrus in the hippocampus is the residence of neuronal progenitor cells (NPCs) that can proliferate and differentiate into newborn mature neurons in sdulthood. This process is called adult hippocampal neurogenesis. Medications such as Temozolamide (TMZ) has been shown to give negative impact on neurogenesis. The aim of this study was to observe the effect of Nigella sativa oil (NSO) on NPCs proliferation after TMZ treatment. This was an experimental study with cross sectional design. Female adult mice (n=20) were housed in 4 groups : control (aquadest per oral (p.o) + NaCl 0,9 % intra peritoneal (i.p)); P0 (aquadest p.o + TMZ i.p); P1 (TMZ i.p + MJH 0,1 ml p.o) ; P2 (TMZ i.p + MJH 0,2 ml p.o.). TMZ was administered at week-2 until week-5, 3 times/week (3 consecutive days). Meanwhile, NSO was administered on week-1 until week-9. On week-6, Brdu was administered i.p to label the proliferating cells in the subgranular zone at that time point. At the end of experiment (week-9) the brains were prepared and stained with 3-3’ diaminobenzidine (DAB) to observe number of BrdU-positive cells. Ratio of BrdU cells in each dentate gyrus area was used as parameter. We found significant decreased in Brdu-positive cells density in TMZ-treated group compared to control, including the groups with NSO treatment. This study showed that TMZ has negative impact on neuronal precursor cells proliferation that cannot be overcome by NSO treatment." @default.
- W3010441512 created "2020-03-13" @default.
- W3010441512 creator A5038371064 @default.
- W3010441512 creator A5046823961 @default.
- W3010441512 creator A5085930601 @default.
- W3010441512 date "2020-03-05" @default.
- W3010441512 modified "2023-09-24" @default.
- W3010441512 title "The Effect of Black Cumin Oil (Nigella Sativa Oil) Supplementation to Prevent Antiproliferative Action of Temozolamide on Hippocampal Neuronal Stem Cells" @default.
- W3010441512 hasPublicationYear "2020" @default.
- W3010441512 type Work @default.
- W3010441512 sameAs 3010441512 @default.
- W3010441512 citedByCount "0" @default.
- W3010441512 crossrefType "journal-article" @default.
- W3010441512 hasAuthorship W3010441512A5038371064 @default.
- W3010441512 hasAuthorship W3010441512A5046823961 @default.
- W3010441512 hasAuthorship W3010441512A5085930601 @default.
- W3010441512 hasConcept C126322002 @default.
- W3010441512 hasConcept C148762608 @default.
- W3010441512 hasConcept C16685009 @default.
- W3010441512 hasConcept C185592680 @default.
- W3010441512 hasConcept C201750760 @default.
- W3010441512 hasConcept C2776464000 @default.
- W3010441512 hasConcept C2777542384 @default.
- W3010441512 hasConcept C2781161787 @default.
- W3010441512 hasConcept C2781176699 @default.
- W3010441512 hasConcept C28328180 @default.
- W3010441512 hasConcept C2993714443 @default.
- W3010441512 hasConcept C4746552 @default.
- W3010441512 hasConcept C556039675 @default.
- W3010441512 hasConcept C71924100 @default.
- W3010441512 hasConcept C86803240 @default.
- W3010441512 hasConcept C95444343 @default.
- W3010441512 hasConcept C98274493 @default.
- W3010441512 hasConceptScore W3010441512C126322002 @default.
- W3010441512 hasConceptScore W3010441512C148762608 @default.
- W3010441512 hasConceptScore W3010441512C16685009 @default.
- W3010441512 hasConceptScore W3010441512C185592680 @default.
- W3010441512 hasConceptScore W3010441512C201750760 @default.
- W3010441512 hasConceptScore W3010441512C2776464000 @default.
- W3010441512 hasConceptScore W3010441512C2777542384 @default.
- W3010441512 hasConceptScore W3010441512C2781161787 @default.
- W3010441512 hasConceptScore W3010441512C2781176699 @default.
- W3010441512 hasConceptScore W3010441512C28328180 @default.
- W3010441512 hasConceptScore W3010441512C2993714443 @default.
- W3010441512 hasConceptScore W3010441512C4746552 @default.
- W3010441512 hasConceptScore W3010441512C556039675 @default.
- W3010441512 hasConceptScore W3010441512C71924100 @default.
- W3010441512 hasConceptScore W3010441512C86803240 @default.
- W3010441512 hasConceptScore W3010441512C95444343 @default.
- W3010441512 hasConceptScore W3010441512C98274493 @default.
- W3010441512 hasIssue "1" @default.
- W3010441512 hasLocation W30104415121 @default.
- W3010441512 hasOpenAccess W3010441512 @default.
- W3010441512 hasPrimaryLocation W30104415121 @default.
- W3010441512 hasRelatedWork W2013424280 @default.
- W3010441512 hasRelatedWork W2013943194 @default.
- W3010441512 hasRelatedWork W2070895177 @default.
- W3010441512 hasRelatedWork W2162774541 @default.
- W3010441512 hasRelatedWork W2293938008 @default.
- W3010441512 hasRelatedWork W2350979381 @default.
- W3010441512 hasRelatedWork W2368692098 @default.
- W3010441512 hasRelatedWork W2374633222 @default.
- W3010441512 hasRelatedWork W2379346489 @default.
- W3010441512 hasRelatedWork W2383549810 @default.
- W3010441512 hasRelatedWork W2385935179 @default.
- W3010441512 hasRelatedWork W2390554045 @default.
- W3010441512 hasRelatedWork W2548170827 @default.
- W3010441512 hasRelatedWork W2560999374 @default.
- W3010441512 hasRelatedWork W2886480677 @default.
- W3010441512 hasRelatedWork W2915472504 @default.
- W3010441512 hasRelatedWork W3080993503 @default.
- W3010441512 hasRelatedWork W3116428218 @default.
- W3010441512 hasRelatedWork W2944951814 @default.
- W3010441512 hasRelatedWork W2995742318 @default.
- W3010441512 hasVolume "45" @default.
- W3010441512 isParatext "false" @default.
- W3010441512 isRetracted "false" @default.
- W3010441512 magId "3010441512" @default.
- W3010441512 workType "article" @default.