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• W3010447564 endingPage "1770" @default.
• W3010447564 startingPage "1770" @default.
• W3010447564 abstract "Insulin, a hormone produced by pancreatic β-cells, has a primary function of maintaining glucose homeostasis. Deficiencies in β-cell insulin secretion result in the development of type 1 and type 2 diabetes, metabolic disorders characterized by high levels of blood glucose. Type 2 diabetes mellitus (T2DM) is characterized by the presence of peripheral insulin resistance in tissues such as skeletal muscle, adipose tissue and liver and develops when β-cells fail to compensate for the peripheral insulin resistance. Insulin resistance triggers a rise in insulin demand and leads to β-cell compensation by increasing both β-cell mass and insulin secretion and leads to the development of hyperinsulinemia. In a vicious cycle, hyperinsulinemia exacerbates the metabolic dysregulations that lead to β-cell failure and the development of T2DM. Insulin and IGF-1 signaling pathways play critical roles in maintaining the differentiated phenotype of β-cells. The autocrine actions of secreted insulin on β-cells is still controversial; work by us and others has shown positive and negative actions by insulin on β-cells. We discuss findings that support the concept of an autocrine action of secreted insulin on β-cells. The hypothesis of whether, during the development of T2DM, secreted insulin initially acts as a friend and contributes to β-cell compensation and then, at a later stage, becomes a foe and contributes to β-cell decompensation will be discussed." @default.
• W3010447564 created "2020-03-13" @default.
• W3010447564 creator A5005705654 @default.
• W3010447564 date "2020-03-05" @default.
• W3010447564 modified "2023-10-11" @default.
• W3010447564 title "Insulin: The Friend and the Foe in the Development of Type 2 Diabetes Mellitus" @default.
• W3010447564 cites W1495740709 @default.
• W3010447564 cites W1514133366 @default.
• W3010447564 cites W1525173771 @default.
• W3010447564 cites W1556383867 @default.
• W3010447564 cites W1621742514 @default.
• W3010447564 cites W1697523131 @default.
• W3010447564 cites W174752440 @default.
• W3010447564 cites W1807852583 @default.
• W3010447564 cites W1841050729 @default.
• W3010447564 cites W1865758164 @default.
• W3010447564 cites W1965262480 @default.
• W3010447564 cites W1965408231 @default.
• W3010447564 cites W1966373813 @default.
• W3010447564 cites W1967005515 @default.
• W3010447564 cites W1969752909 @default.
• W3010447564 cites W1971141707 @default.
• W3010447564 cites W1971286863 @default.
• W3010447564 cites W1974842079 @default.
• W3010447564 cites W1974894120 @default.
• W3010447564 cites W1975941334 @default.
• W3010447564 cites W1978030502 @default.
• W3010447564 cites W1979532631 @default.
• W3010447564 cites W1980136845 @default.
• W3010447564 cites W1981747327 @default.
• W3010447564 cites W1982060139 @default.
• W3010447564 cites W1984188550 @default.
• W3010447564 cites W1984359443 @default.
• W3010447564 cites W1985149672 @default.
• W3010447564 cites W1988882421 @default.
• W3010447564 cites W1989246214 @default.
• W3010447564 cites W1989774085 @default.
• W3010447564 cites W1991710558 @default.
• W3010447564 cites W1992002046 @default.
• W3010447564 cites W1992008474 @default.
• W3010447564 cites W1992968276 @default.
• W3010447564 cites W1993719296 @default.
• W3010447564 cites W1995491925 @default.
• W3010447564 cites W1995646241 @default.
• W3010447564 cites W1995707166 @default.
• W3010447564 cites W1995812738 @default.
• W3010447564 cites W1996303883 @default.
• W3010447564 cites W1997146974 @default.
• W3010447564 cites W1998493448 @default.
• W3010447564 cites W1998745868 @default.
• W3010447564 cites W1999806215 @default.
• W3010447564 cites W2000412931 @default.
• W3010447564 cites W2001161494 @default.
• W3010447564 cites W2002014786 @default.
• W3010447564 cites W2004313228 @default.
• W3010447564 cites W2005642589 @default.
• W3010447564 cites W2005870046 @default.
• W3010447564 cites W2008701006 @default.
• W3010447564 cites W2009710495 @default.
• W3010447564 cites W2009885004 @default.
• W3010447564 cites W2010523407 @default.
• W3010447564 cites W2011506953 @default.
• W3010447564 cites W2012621681 @default.
• W3010447564 cites W2015732174 @default.
• W3010447564 cites W2016496308 @default.
• W3010447564 cites W2017391547 @default.
• W3010447564 cites W2019361290 @default.
• W3010447564 cites W2019372747 @default.
• W3010447564 cites W2019926410 @default.
• W3010447564 cites W2021049560 @default.
• W3010447564 cites W2021925516 @default.
• W3010447564 cites W2022528925 @default.
• W3010447564 cites W2024067973 @default.
• W3010447564 cites W2024360162 @default.
• W3010447564 cites W2025578932 @default.
• W3010447564 cites W2026045809 @default.
• W3010447564 cites W2026509244 @default.
• W3010447564 cites W2028415754 @default.
• W3010447564 cites W2029526781 @default.
• W3010447564 cites W2029693362 @default.
• W3010447564 cites W2034451334 @default.
• W3010447564 cites W2034712114 @default.
• W3010447564 cites W2037266625 @default.
• W3010447564 cites W2039928997 @default.
• W3010447564 cites W2040595653 @default.
• W3010447564 cites W2040692229 @default.
• W3010447564 cites W2041739600 @default.
• W3010447564 cites W2042268825 @default.
• W3010447564 cites W2042381753 @default.
• W3010447564 cites W2044801671 @default.
• W3010447564 cites W2044927096 @default.
• W3010447564 cites W2046406719 @default.
• W3010447564 cites W2047169725 @default.
• W3010447564 cites W2052347872 @default.
• W3010447564 cites W2055732466 @default.
• W3010447564 cites W2059082073 @default.
• W3010447564 cites W2063801212 @default.
• W3010447564 cites W2064417575 @default.

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