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• W3010458007 abstract "Abstract Background Inactivating mutations in the gene for cartilage‐associated protein (CRTAP) cause osteogenesis imperfecta type VII in humans, with a phenotype that can include craniofacial defects. Dental and craniofacial manifestations have not been a focus of case reports to date. We analyzed the craniofacial and dental phenotype of Crtap −/− mice by skull measurements, micro‐computed tomography (micro‐CT), histology, and immunohistochemistry. Results Crtap −/− mice exhibited a brachycephalic skull shape with fusion of the nasofrontal suture and facial bones, resulting in mid‐face retrusion and a class III dental malocclusion. Loss of CRTAP also resulted in decreased dentin volume and decreased cellular cementum volume, though acellular cementum thickness was increased. Periodontal dysfunction was revealed by decreased alveolar bone volume and mineral density, increased periodontal ligament (PDL) space, ectopic calcification within the PDL, bone‐tooth ankylosis, altered immunostaining of extracellular matrix proteins in bone and PDL, increased pSMAD5, and more numerous osteoclasts on alveolar bone surfaces. Conclusions Crtap −/− mice serve as a useful model of the dental and craniofacial abnormalities seen in individuals with osteogenesis imperfecta type VII." @default.
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• W3010458007 date "2020-03-12" @default.
• W3010458007 modified "2023-10-17" @default.
• W3010458007 title "Dental and craniofacial defects in the <i>Crtap^−/−</i> mouse model of osteogenesis imperfecta type VII" @default.
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• W3010458007 doi "https://doi.org/10.1002/dvdy.166" @default.
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