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• W3010499169 abstract "Japanese cedar pollinosis (JCP) is a common affliction caused by an allergic reaction to cedar pollen and is considered a disease of national importance in Japan. Antigen-specific immunotherapy (AIT) is the only available curative treatment for JCP. However, low compliance and persistence have been reported among patients subcutaneously or sublingually administered AIT comprising a conventional antigen derived from a pollen extract. To address these issues, many research studies have focused on developing a safer, simpler, and more effective AIT for JCP. Here, we review the novel antigens that have been developed for JCP AIT, discuss their different administration routes, and present the effects of anti-allergy treatment. Then, we describe a new form of AIT called transcutaneous immunotherapy (TCIT) and its solid-in-oil (S/O) nanodispersion formulation, which is a promising antigen delivery system. Finally, we discuss the applications of S/O nanodispersions for JCP TCIT. In this context, we predict that TCIT delivery by using a S/O nanodispersion loaded with novel antigens may offer an easier, safer, and more effective treatment option for JCP patients." @default.
• W3010499169 created "2020-03-13" @default.
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• W3010499169 date "2020-03-07" @default.
• W3010499169 modified "2023-09-26" @default.
• W3010499169 title "Solid-in-Oil Nanodispersions for Transcutaneous Immunotherapy of Japanese Cedar Pollinosis" @default.
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• W3010499169 doi "https://doi.org/10.3390/pharmaceutics12030240" @default.
• W3010499169 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7150915" @default.
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• W3010499169 hasPublicationYear "2020" @default.
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