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• W3010511703 abstract "Copper nanoparticles (Cu NPs) has been extensively synthesized in various industrialand commercial applications to perform its multifunctional properties such as antifungaland antibacterial. In this study, copper nanoparticle synthesis, characterization usingscanning electron microscope (SEM), X-ray diffraction (XRD) and cytotoxic effect ofthe impregnated copper nanoparticles insoles towards mammalian cell lines wereperformed. This study aims to synthesize and characterize the copper particles and toevaluate the of cytotoxicity effect of the insole impregnated with Cu NPs towardsmammalian cells via an in vitro model. Cu NPs were synthesized by using chemicalreduction method and the sizes were confirmed by SEM and XRD analysis. The SEMresults showed low distribution of Cu NPs and size in the range of 89.80 nm to 393.9nm. XRD results showed the crystalline nature with peaks corresponding to Cu NPs andsilica particles, the average size of Cu NPs was between 28 to 57 nm. The insolesimpregnated with Cu NPs were then assessed for toxicity effect in human dermalfibroblast (HDF) cells and human hepatocellular carcinoma cells (HepG2) by usingmicroculture tetrazolium (MTT) assay for cell viability. This biological evaluation wasperformed via indirect contact method. The leachate growth medium were prepared forcytotoxicity analysis instead of exposing cell lines to impregnated insoles directly. Thesix treatments include insole coated with Cu particles, Cu with ethylene glycol (EG),copper precursor (Cu(NH3)4(OH)2), Cu(NH3)4(OH)2 with EG, EG and insole withoutcoating. The positive control was 30% v/v DMSO whereas negative control wasmedium without insole. The insoles were immersed into Dulbecco modified Eaglemedium (DMEM) for 4 hours. The leachates medium solution from 4 hours wereincubated with the cell lines for 24 hours prior for cytotoxicity testing. The comparativeeffects on the types of cell lines on cell viability were studied in MTT assay, but in HDFcells showed negative result with no significant data between positive and negativecontrol. Morphologically, the HDF passage 17 showed healthy after treatments butunable to uptake MTT reagent. HepG2 cells showed significant difference (P<0.05)between treated and untreated cells. In conclusion, Cu NPs synthesis method isenvironmental friendly and cost effective. Cu NPs coated insoles have the potential forpractical application based on its targeted antimicrobial effect reported previously. Thetoxicity of Cu NPs, copper precursor and ethylene glycol was observed in HepG2 andcaused the cell viability to decrease. However, cytotoxicity effect on HDF cells was notconclusive in the current investigation due to cell condition was not in ideal condition." @default.
• W3010511703 created "2020-03-13" @default.
• W3010511703 creator A5035177319 @default.
• W3010511703 date "2019-01-01" @default.
• W3010511703 modified "2023-09-24" @default.
• W3010511703 title "Synthesis, Characterization and Cytotoxic Evaluation ofInsoles Impregnated with Copper Nanoparticles" @default.
• W3010511703 hasPublicationYear "2019" @default.
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