FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010535785> ?p ?o ?g. }

• W3010535785 abstract "Abstract IgE production against innocuous antigens can lead to life-threatening reactions such as anaphylaxis. While IgE levels drastically decline with strict allergen avoidance, the ability to regenerate IgE can persist for a lifetime, as is the case for peanut allergy. The mechanism by which IgE regenerates remains unresolved. A novel culture system and application of single-cell RNA-sequencing, elucidated the transcriptomic signature of human peanut-reactive B and T cells and revealed IL-4/IL-13 as a signaling pathway critical for the IgE recall response. Indeed, interruption of this pathway not only prevented IgE production and anaphylaxis, but also reprogrammed the pathogenic response against peanut. This investigation advances our understanding of the mechanism that regenerates IgE in food allergy and spotlights IL-4/IL-13 blockade as a therapeutic with disease-transforming potential. One Sentence Summary Single-cell transcriptomics of allergic memory responses reveals how to teach the immune system to forget." @default.
• W3010535785 created "2020-03-13" @default.
• W3010535785 creator A5003112315 @default.
• W3010535785 creator A5007819120 @default.
• W3010535785 creator A5008590939 @default.
• W3010535785 creator A5013565146 @default.
• W3010535785 creator A5048737172 @default.
• W3010535785 creator A5049209739 @default.
• W3010535785 creator A5062141566 @default.
• W3010535785 creator A5065277319 @default.
• W3010535785 creator A5066462262 @default.
• W3010535785 creator A5070308889 @default.
• W3010535785 creator A5072308457 @default.
• W3010535785 creator A5073056241 @default.
• W3010535785 creator A5075050803 @default.
• W3010535785 creator A5076319453 @default.
• W3010535785 creator A5079201163 @default.
• W3010535785 creator A5084851726 @default.
• W3010535785 creator A5088084481 @default.
• W3010535785 date "2020-03-05" @default.
• W3010535785 modified "2023-09-25" @default.
• W3010535785 title "Interrupting reactivation of immunological memory reprograms allergy and averts anaphylaxis" @default.
• W3010535785 cites W1160163724 @default.
• W3010535785 cites W1974356101 @default.
• W3010535785 cites W2007565796 @default.
• W3010535785 cites W2009968823 @default.
• W3010535785 cites W2056238200 @default.
• W3010535785 cites W2063105199 @default.
• W3010535785 cites W2066139776 @default.
• W3010535785 cites W2118630839 @default.
• W3010535785 cites W2143235674 @default.
• W3010535785 cites W2476169976 @default.
• W3010535785 cites W2581513664 @default.
• W3010535785 cites W2600152191 @default.
• W3010535785 cites W2741189881 @default.
• W3010535785 cites W2754428040 @default.
• W3010535785 cites W2803941918 @default.
• W3010535785 cites W2804024167 @default.
• W3010535785 cites W2895697103 @default.
• W3010535785 cites W2903856687 @default.
• W3010535785 cites W2930143113 @default.
• W3010535785 cites W2949177718 @default.
• W3010535785 cites W3001560298 @default.
• W3010535785 doi "https://doi.org/10.1101/2020.03.04.975706" @default.
• W3010535785 hasPublicationYear "2020" @default.
• W3010535785 type Work @default.
• W3010535785 sameAs 3010535785 @default.
• W3010535785 citedByCount "2" @default.
• W3010535785 countsByYear W30105357852020 @default.
• W3010535785 countsByYear W30105357852021 @default.
• W3010535785 crossrefType "posted-content" @default.
• W3010535785 hasAuthorship W3010535785A5003112315 @default.
• W3010535785 hasAuthorship W3010535785A5007819120 @default.
• W3010535785 hasAuthorship W3010535785A5008590939 @default.
• W3010535785 hasAuthorship W3010535785A5013565146 @default.
• W3010535785 hasAuthorship W3010535785A5048737172 @default.
• W3010535785 hasAuthorship W3010535785A5049209739 @default.
• W3010535785 hasAuthorship W3010535785A5062141566 @default.
• W3010535785 hasAuthorship W3010535785A5065277319 @default.
• W3010535785 hasAuthorship W3010535785A5066462262 @default.
• W3010535785 hasAuthorship W3010535785A5070308889 @default.
• W3010535785 hasAuthorship W3010535785A5072308457 @default.
• W3010535785 hasAuthorship W3010535785A5073056241 @default.
• W3010535785 hasAuthorship W3010535785A5075050803 @default.
• W3010535785 hasAuthorship W3010535785A5076319453 @default.
• W3010535785 hasAuthorship W3010535785A5079201163 @default.
• W3010535785 hasAuthorship W3010535785A5084851726 @default.
• W3010535785 hasAuthorship W3010535785A5088084481 @default.
• W3010535785 hasBestOaLocation W30105357851 @default.
• W3010535785 hasConcept C111472728 @default.
• W3010535785 hasConcept C138885662 @default.
• W3010535785 hasConcept C141105273 @default.
• W3010535785 hasConcept C147483822 @default.
• W3010535785 hasConcept C159654299 @default.
• W3010535785 hasConcept C203014093 @default.
• W3010535785 hasConcept C207480886 @default.
• W3010535785 hasConcept C2775933838 @default.
• W3010535785 hasConcept C2776953665 @default.
• W3010535785 hasConcept C2778012357 @default.
• W3010535785 hasConcept C71924100 @default.
• W3010535785 hasConcept C86803240 @default.
• W3010535785 hasConcept C8891405 @default.
• W3010535785 hasConcept C89611455 @default.
• W3010535785 hasConceptScore W3010535785C111472728 @default.
• W3010535785 hasConceptScore W3010535785C138885662 @default.
• W3010535785 hasConceptScore W3010535785C141105273 @default.
• W3010535785 hasConceptScore W3010535785C147483822 @default.
• W3010535785 hasConceptScore W3010535785C159654299 @default.
• W3010535785 hasConceptScore W3010535785C203014093 @default.
• W3010535785 hasConceptScore W3010535785C207480886 @default.
• W3010535785 hasConceptScore W3010535785C2775933838 @default.
• W3010535785 hasConceptScore W3010535785C2776953665 @default.
• W3010535785 hasConceptScore W3010535785C2778012357 @default.
• W3010535785 hasConceptScore W3010535785C71924100 @default.
• W3010535785 hasConceptScore W3010535785C86803240 @default.
• W3010535785 hasConceptScore W3010535785C8891405 @default.
• W3010535785 hasConceptScore W3010535785C89611455 @default.
• W3010535785 hasLocation W30105357851 @default.
• W3010535785 hasOpenAccess W3010535785 @default.
• W3010535785 hasPrimaryLocation W30105357851 @default.

• next