Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010590094> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W3010590094 abstract "To explore the effects of hesperidin on glycolipid metabolic disorders and its mechanism in mice induced by high-fat diet, 40 male C57 mice were randomly divided into control group, OB group, low dose group (OB+ hes-low) and high dose group (OB+ hes-high) according to the diet. After 16 weeks, the body weight, liver index and visceral fat index in all mice were detected. The glucose metabolism indications (blood glucose, insulin levels and HOMA-IR) and serum lipid levels were evaluated. The mRNA expression of insulin signaling pathway genes(IR, IRS1, Glut2, Glut4), lipid metabolism pathway genes(SREBP-1c, FAS, ACC, PPARα) and AMPK were analyzed by Real-time PCR. After 16-week feeding, the indicators in OB group were higher than those in control group, including body weight, body fat deposition, serum glucose, serum lipid, serum insulin and HOMA-IR index (P<0.05). And impaired glucose tolerance occurred in the OB group (P<0.05). Treating with hesperidin, whether in low or high dose, attenuated these changes (P<0.05), especially in high dose group(P<0.05). Hesperidin, especially in high dose, upregulated the mRNA expressions of AMPK (P<0.05), which had impact on the gene expressions of insulin signaling pathway (IR, IRS-1, Glut2/4) (P<0.05) and lipid metabolism related genes (SREBP-1c and Fas and ACC) (P<0.05). The activatory effect of hesperidin on the mRNA expressions of PPARα was also observed (P<0.05), especially in high dose group (P<0.05). Hesperidin inhibits obesity, hyperglycemia, hyperlipemia and attenuates insulin resistance. These effects might be closed related to the activation of AMPK, which regulate the insulin signaling pathway and lipid metabolism." @default.
- W3010590094 created "2020-03-13" @default.
- W3010590094 creator A5047485845 @default.
- W3010590094 date "2016-09-01" @default.
- W3010590094 modified "2023-10-03" @default.
- W3010590094 title "Protection mechanisms of hesperidin on mouse with insulin resistance" @default.
- W3010590094 doi "https://doi.org/10.4268/cjcmm20161728" @default.
- W3010590094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28920385" @default.
- W3010590094 hasPublicationYear "2016" @default.
- W3010590094 type Work @default.
- W3010590094 sameAs 3010590094 @default.
- W3010590094 citedByCount "7" @default.
- W3010590094 countsByYear W30105900942019 @default.
- W3010590094 countsByYear W30105900942020 @default.
- W3010590094 countsByYear W30105900942021 @default.
- W3010590094 countsByYear W30105900942022 @default.
- W3010590094 crossrefType "journal-article" @default.
- W3010590094 hasAuthorship W3010590094A5047485845 @default.
- W3010590094 hasConcept C126322002 @default.
- W3010590094 hasConcept C134018914 @default.
- W3010590094 hasConcept C142724271 @default.
- W3010590094 hasConcept C161573976 @default.
- W3010590094 hasConcept C17093226 @default.
- W3010590094 hasConcept C181199279 @default.
- W3010590094 hasConcept C185592680 @default.
- W3010590094 hasConcept C204787440 @default.
- W3010590094 hasConcept C2776128092 @default.
- W3010590094 hasConcept C2776188179 @default.
- W3010590094 hasConcept C2777391703 @default.
- W3010590094 hasConcept C2777901630 @default.
- W3010590094 hasConcept C2779306644 @default.
- W3010590094 hasConcept C2780124434 @default.
- W3010590094 hasConcept C4733338 @default.
- W3010590094 hasConcept C55493867 @default.
- W3010590094 hasConcept C71924100 @default.
- W3010590094 hasConcept C86803240 @default.
- W3010590094 hasConcept C97029542 @default.
- W3010590094 hasConceptScore W3010590094C126322002 @default.
- W3010590094 hasConceptScore W3010590094C134018914 @default.
- W3010590094 hasConceptScore W3010590094C142724271 @default.
- W3010590094 hasConceptScore W3010590094C161573976 @default.
- W3010590094 hasConceptScore W3010590094C17093226 @default.
- W3010590094 hasConceptScore W3010590094C181199279 @default.
- W3010590094 hasConceptScore W3010590094C185592680 @default.
- W3010590094 hasConceptScore W3010590094C204787440 @default.
- W3010590094 hasConceptScore W3010590094C2776128092 @default.
- W3010590094 hasConceptScore W3010590094C2776188179 @default.
- W3010590094 hasConceptScore W3010590094C2777391703 @default.
- W3010590094 hasConceptScore W3010590094C2777901630 @default.
- W3010590094 hasConceptScore W3010590094C2779306644 @default.
- W3010590094 hasConceptScore W3010590094C2780124434 @default.
- W3010590094 hasConceptScore W3010590094C4733338 @default.
- W3010590094 hasConceptScore W3010590094C55493867 @default.
- W3010590094 hasConceptScore W3010590094C71924100 @default.
- W3010590094 hasConceptScore W3010590094C86803240 @default.
- W3010590094 hasConceptScore W3010590094C97029542 @default.
- W3010590094 hasLocation W30105900941 @default.
- W3010590094 hasLocation W30105900942 @default.
- W3010590094 hasOpenAccess W3010590094 @default.
- W3010590094 hasPrimaryLocation W30105900941 @default.
- W3010590094 hasRelatedWork W1964178409 @default.
- W3010590094 hasRelatedWork W2051897775 @default.
- W3010590094 hasRelatedWork W2070282895 @default.
- W3010590094 hasRelatedWork W2096420073 @default.
- W3010590094 hasRelatedWork W2103856172 @default.
- W3010590094 hasRelatedWork W2155465717 @default.
- W3010590094 hasRelatedWork W2410784692 @default.
- W3010590094 hasRelatedWork W3010590094 @default.
- W3010590094 hasRelatedWork W3113810870 @default.
- W3010590094 hasRelatedWork W2187880709 @default.
- W3010590094 isParatext "false" @default.
- W3010590094 isRetracted "false" @default.
- W3010590094 magId "3010590094" @default.
- W3010590094 workType "article" @default.