FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010597213> ?p ?o ?g. }

• W3010597213 endingPage "175883592090753" @default.
• W3010597213 startingPage "175883592090753" @default.
• W3010597213 abstract "Conventional treatments for follicular thyroid cancer (FTC) can be ineffective, leading to poor prognosis. The aim of this study was to identify mutations associated with FTC that would serve as novel molecular markers of the disease and its outcome and could potentially identify new therapeutic targets.FLT3 mutations were first detected in a 29-year-old White female diagnosed with metastasized, treatment-refractory FTC. Analyses of FLT3 mutational status through next-generation sequencing of formalin-fixed, paraffin-embedded FTC specimens were subsequently performed in 35 randomly selected patients diagnosed with FTC.FLT3 mutations were found in 69% of patients. FLT3 mutation-positive patients were significantly older than those that were FLT3 mutation-negative [median age at diagnosis 54 (36-82) versus 45 (27-58) (p = 0.023)]. Patients over 60 years were 23 times more likely to be FLT3 mutation-positive (p = 0.006). However, the number of FLT3 mutations did not correlate with age (r-Pearson: -0.244, p-value: 0.25). A total of 26 mutations were identified in the FLT3 gene with 2-16 FLT3 mutations in each FLT3 mutation-positive patient (mean: 5.6 mutations/patient). Tyrosine kinase domain (TKD) mutations in the FLT3 gene were detected in 58% of FLT3 mutation-positive patients. All FLT3 mutation-positive patients with a disease stage of pT2N1 or worse harbored at least one mutation in the TKD of FLT3.There is a wide spectrum and high frequency of FLT3 mutations in FTC. The precise role of FLT3 mutations in the genesis of FTC, as well as its potential role as a therapeutic target, requires further investigation." @default.
• W3010597213 created "2020-03-13" @default.
• W3010597213 creator A5014702945 @default.
• W3010597213 creator A5015412172 @default.
• W3010597213 creator A5019040298 @default.
• W3010597213 creator A5030196705 @default.
• W3010597213 creator A5055013386 @default.
• W3010597213 creator A5055078844 @default.
• W3010597213 creator A5058401326 @default.
• W3010597213 creator A5059850327 @default.
• W3010597213 creator A5065916792 @default.
• W3010597213 creator A5070459149 @default.
• W3010597213 creator A5075685000 @default.
• W3010597213 creator A5078009975 @default.
• W3010597213 creator A5080556225 @default.
• W3010597213 date "2020-01-01" @default.
• W3010597213 modified "2023-09-23" @default.
• W3010597213 title "High incidence of <i>FLT3</i> mutations in follicular thyroid cancer: potential therapeutic target in patients with advanced disease stage" @default.
• W3010597213 cites W1496613889 @default.
• W3010597213 cites W1569806610 @default.
• W3010597213 cites W1970413157 @default.
• W3010597213 cites W1975137294 @default.
• W3010597213 cites W1984209370 @default.
• W3010597213 cites W1993236149 @default.
• W3010597213 cites W2017107901 @default.
• W3010597213 cites W2018852356 @default.
• W3010597213 cites W2026221655 @default.
• W3010597213 cites W2026251282 @default.
• W3010597213 cites W2038146919 @default.
• W3010597213 cites W2045166052 @default.
• W3010597213 cites W2050849384 @default.
• W3010597213 cites W2054794987 @default.
• W3010597213 cites W2056465113 @default.
• W3010597213 cites W2059035027 @default.
• W3010597213 cites W2059145105 @default.
• W3010597213 cites W2064051300 @default.
• W3010597213 cites W2083127665 @default.
• W3010597213 cites W2097121408 @default.
• W3010597213 cites W2100303227 @default.
• W3010597213 cites W2103177765 @default.
• W3010597213 cites W2109726093 @default.
• W3010597213 cites W2115400012 @default.
• W3010597213 cites W2130864403 @default.
• W3010597213 cites W2139785513 @default.
• W3010597213 cites W2142453541 @default.
• W3010597213 cites W2143238378 @default.
• W3010597213 cites W2145150141 @default.
• W3010597213 cites W2162098634 @default.
• W3010597213 cites W2163288750 @default.
• W3010597213 cites W2169076372 @default.
• W3010597213 cites W2172253373 @default.
• W3010597213 cites W2192272998 @default.
• W3010597213 cites W2299670551 @default.
• W3010597213 cites W2377402344 @default.
• W3010597213 cites W2412183643 @default.
• W3010597213 cites W2478132860 @default.
• W3010597213 cites W2510458758 @default.
• W3010597213 cites W2715749014 @default.
• W3010597213 cites W2768523107 @default.
• W3010597213 cites W2770900102 @default.
• W3010597213 cites W2793662479 @default.
• W3010597213 cites W2794542252 @default.
• W3010597213 cites W2801504839 @default.
• W3010597213 cites W2805480504 @default.
• W3010597213 cites W2955197958 @default.
• W3010597213 cites W2972731908 @default.
• W3010597213 cites W2976551368 @default.
• W3010597213 cites W849272724 @default.
• W3010597213 doi "https://doi.org/10.1177/1758835920907534" @default.
• W3010597213 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7057406" @default.
• W3010597213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32180839" @default.
• W3010597213 hasPublicationYear "2020" @default.
• W3010597213 type Work @default.
• W3010597213 sameAs 3010597213 @default.
• W3010597213 citedByCount "1" @default.
• W3010597213 countsByYear W30105972132023 @default.
• W3010597213 crossrefType "journal-article" @default.
• W3010597213 hasAuthorship W3010597213A5014702945 @default.
• W3010597213 hasAuthorship W3010597213A5015412172 @default.
• W3010597213 hasAuthorship W3010597213A5019040298 @default.
• W3010597213 hasAuthorship W3010597213A5030196705 @default.
• W3010597213 hasAuthorship W3010597213A5055013386 @default.
• W3010597213 hasAuthorship W3010597213A5055078844 @default.
• W3010597213 hasAuthorship W3010597213A5058401326 @default.
• W3010597213 hasAuthorship W3010597213A5059850327 @default.
• W3010597213 hasAuthorship W3010597213A5065916792 @default.
• W3010597213 hasAuthorship W3010597213A5070459149 @default.
• W3010597213 hasAuthorship W3010597213A5075685000 @default.
• W3010597213 hasAuthorship W3010597213A5078009975 @default.
• W3010597213 hasAuthorship W3010597213A5080556225 @default.
• W3010597213 hasBestOaLocation W30105972131 @default.
• W3010597213 hasConcept C104317684 @default.
• W3010597213 hasConcept C121608353 @default.
• W3010597213 hasConcept C126322002 @default.
• W3010597213 hasConcept C143998085 @default.
• W3010597213 hasConcept C146357865 @default.
• W3010597213 hasConcept C151730666 @default.
• W3010597213 hasConcept C2779134260 @default.

• next