FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010606543> ?p ?o ?g. }

• W3010606543 endingPage "42" @default.
• W3010606543 startingPage "33" @default.
• W3010606543 abstract "Photo-crosslinkable polymers have a great potential for the delivery of sensitive drugs. They allow preparation of drug releasing devices by photo-crosslinking, thus avoiding high processing temperatures. In this study, the hydrolysis behavior and drug release of three different photo-crosslinkable poly(ether anhydride)s and one poly(ester anhydride) were investigated. Three-arm poly(ethylene glycol) or polycaprolactone was reacted with succinic anhydride to obtain carboxylated macromers, and further functionalized with methacrylic anhydride to form methacrylated marcromers with anhydride linkages. The synthetized macromers were used to prepare photo-crosslinked matrices with different hydrolytic degradation times for active agent release purposes. The hydrolysis was clearly pH-sensitive: polymer networks degraded slowly in acidic conditions, and degradation rate increased as the pH shifted towards basic conditions. Drug release was studied with two water-soluble model drugs lidocaine (234 mol/g) and vitamin B12 (1355 g/mol). Vitamin B12 was released mainly due to polymer network degradation, whereas smaller molecule lidocaine was released also through diffusion and swelling of polymer network. Only a small amount of vitamin B12 was released in acidic conditions (pH 1.3 and pH 2.1). These polymers have potential in colon targeted drug delivery as the polymer could protect sensitive drugs from acidic conditions in the stomach, and the drug would be released as the conditions change closer to neutral pH in the intestine." @default.
• W3010606543 created "2020-03-13" @default.
• W3010606543 creator A5012756411 @default.
• W3010606543 creator A5083687797 @default.
• W3010606543 date "2020-05-01" @default.
• W3010606543 modified "2023-10-14" @default.
• W3010606543 title "Photo-crosslinked anhydride-modified polyester and –ethers for pH-sensitive drug release" @default.
• W3010606543 cites W1549826455 @default.
• W3010606543 cites W1830447782 @default.
• W3010606543 cites W1964369590 @default.
• W3010606543 cites W1965171634 @default.
• W3010606543 cites W1965884363 @default.
• W3010606543 cites W1969038105 @default.
• W3010606543 cites W197010566 @default.
• W3010606543 cites W1987193289 @default.
• W3010606543 cites W1991814072 @default.
• W3010606543 cites W1995645236 @default.
• W3010606543 cites W1996844557 @default.
• W3010606543 cites W2010506651 @default.
• W3010606543 cites W2011582184 @default.
• W3010606543 cites W2015463680 @default.
• W3010606543 cites W2018046494 @default.
• W3010606543 cites W2018241449 @default.
• W3010606543 cites W2022272798 @default.
• W3010606543 cites W2027074333 @default.
• W3010606543 cites W2046627126 @default.
• W3010606543 cites W2050207992 @default.
• W3010606543 cites W2052480807 @default.
• W3010606543 cites W2053630373 @default.
• W3010606543 cites W2063926504 @default.
• W3010606543 cites W2066083399 @default.
• W3010606543 cites W2067613014 @default.
• W3010606543 cites W2072624182 @default.
• W3010606543 cites W2073848656 @default.
• W3010606543 cites W2076514712 @default.
• W3010606543 cites W2077237690 @default.
• W3010606543 cites W2087933081 @default.
• W3010606543 cites W2095600570 @default.
• W3010606543 cites W2105008855 @default.
• W3010606543 cites W2121193807 @default.
• W3010606543 cites W2124696441 @default.
• W3010606543 cites W2131633427 @default.
• W3010606543 cites W2135354796 @default.
• W3010606543 cites W2135376591 @default.
• W3010606543 cites W2140863909 @default.
• W3010606543 cites W2148766872 @default.
• W3010606543 cites W2157189533 @default.
• W3010606543 cites W2160011394 @default.
• W3010606543 cites W2162294498 @default.
• W3010606543 cites W2167832151 @default.
• W3010606543 cites W2395523081 @default.
• W3010606543 cites W2765562693 @default.
• W3010606543 cites W2795325405 @default.
• W3010606543 cites W2799698038 @default.
• W3010606543 cites W2883995473 @default.
• W3010606543 cites W2913665292 @default.
• W3010606543 cites W2947632647 @default.
• W3010606543 cites W2947948568 @default.
• W3010606543 cites W4302216514 @default.
• W3010606543 cites W862411811 @default.
• W3010606543 doi "https://doi.org/10.1016/j.ejpb.2020.02.015" @default.
• W3010606543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32142953" @default.
• W3010606543 hasPublicationYear "2020" @default.
• W3010606543 type Work @default.
• W3010606543 sameAs 3010606543 @default.
• W3010606543 citedByCount "4" @default.
• W3010606543 countsByYear W30106065432020 @default.
• W3010606543 countsByYear W30106065432021 @default.
• W3010606543 countsByYear W30106065432022 @default.
• W3010606543 crossrefType "journal-article" @default.
• W3010606543 hasAuthorship W3010606543A5012756411 @default.
• W3010606543 hasAuthorship W3010606543A5083687797 @default.
• W3010606543 hasBestOaLocation W30106065432 @default.
• W3010606543 hasConcept C119394753 @default.
• W3010606543 hasConcept C13245373 @default.
• W3010606543 hasConcept C159985019 @default.
• W3010606543 hasConcept C178790620 @default.
• W3010606543 hasConcept C185592680 @default.
• W3010606543 hasConcept C188027245 @default.
• W3010606543 hasConcept C192562407 @default.
• W3010606543 hasConcept C2777516009 @default.
• W3010606543 hasConcept C2777735259 @default.
• W3010606543 hasConcept C2778540859 @default.
• W3010606543 hasConcept C2779820397 @default.
• W3010606543 hasConcept C2779868350 @default.
• W3010606543 hasConcept C521977710 @default.
• W3010606543 hasConcept C94412978 @default.
• W3010606543 hasConceptScore W3010606543C119394753 @default.
• W3010606543 hasConceptScore W3010606543C13245373 @default.
• W3010606543 hasConceptScore W3010606543C159985019 @default.
• W3010606543 hasConceptScore W3010606543C178790620 @default.
• W3010606543 hasConceptScore W3010606543C185592680 @default.
• W3010606543 hasConceptScore W3010606543C188027245 @default.
• W3010606543 hasConceptScore W3010606543C192562407 @default.
• W3010606543 hasConceptScore W3010606543C2777516009 @default.
• W3010606543 hasConceptScore W3010606543C2777735259 @default.
• W3010606543 hasConceptScore W3010606543C2778540859 @default.
• W3010606543 hasConceptScore W3010606543C2779820397 @default.

• next