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- W3010627146 endingPage "980" @default.
- W3010627146 startingPage "973" @default.
- W3010627146 abstract "Abstract Mammalian sirtuins (SIRTs 1‐7) are a family of NAD+‐dependent deacetylases with distinct subcellular localization and biological functions that regulate various important cellular processes. Among these, SIRTs ‐3, ‐4 and ‐5 are located in the mitochondria and have been implicated in caloric restriction, oxidative stress, aging and various human diseases. Emerging evidence has found dysregulation of mitochondrial sirtuins in multiple dermatological conditions, including responses to ultraviolet radiation (UVR), suggesting their importance in maintaining skin health. In this review, we discuss the roles and implications of mitochondrial sirtuins in cutaneous cellular processes, and their emerging potential as a target for the management of skin diseases, including skin cancer. Among mitochondrial sirtuins, SIRT3 is the most studied and linked to multiple skin conditions and diseases (keratinocyte differentiation, wound healing, chronological aging, UVR and ozone response, systemic sclerosis, melanoma, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)). SIRT4 has been connected to keratinocyte differentiation, chronological aging, UVR response, alopecia, BCC and SCC. Further, SIRT5 has been associated with keratinocyte differentiation, melanoma, BCC and SCC. Overall, while there is compelling evidence for the involvement of mitochondrial sirtuins in skin, additional detailed studies are needed to understand their exact roles in skin and skin cancers." @default.
- W3010627146 created "2020-03-13" @default.
- W3010627146 creator A5025592530 @default.
- W3010627146 creator A5042168434 @default.
- W3010627146 creator A5044445781 @default.
- W3010627146 creator A5045348217 @default.
- W3010627146 date "2020-04-28" @default.
- W3010627146 modified "2023-09-26" @default.
- W3010627146 title "Mitochondrial Sirtuins in Skin and Skin Cancers" @default.
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