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- W3010629691 abstract "The discovery of new molecules for fighting against malaria is still relevant to overcome <i>Plasmodium</i> sp resistance. Phenolic compounds from medicinal plants have shown antiplasmodial properties. In addition, the targets of flavonoids on <i>P. falciparum</i> are multiple. This work aimed to identify the antiplasmodial compounds from methanol extract of <i>Securidaca longepedunculata</i> leaves. The inhibition of β-hematin formation was used to detect antiplasmodial compounds through a bio-guided chromatographic fractionation procedures. W2 strain was inhibited by flavonoids fractions Fc1 and Fb4 with 6.98 and 10.39 µg/mL as IC<sub>50</sub> respectively. Also, fractions of phenol acids have shown good activities on the inhibition of β-hematin formation. The HPLC analyze showed that <i>S. longepedunculata</i> leaves extract contained quercetin, 3-β-quercetin, luteolin, chrysin, isorhamnetin, hyperoside, rutin, gallic acid, ellagic acid, chlorogenic acid, tannic acid and ferulic acid. Among these compounds identified, some had shown antiplasmodial and inhibitory activities on the formation of β-hematin. The antimalarial activity of the leaves of S. longepedunculata would be due in part to phenolic acids and flavonoids. The antiplasmodial activity observed in this work would be due in part to the ability of flavonoids from S. longepedunculata leaves to inhibit the formation of β-hematin. This finding could justify partially the <i>S. longepedunculata</i> uses in malaria treatment in Burkina Faso." @default.
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- W3010629691 date "2020-01-01" @default.
- W3010629691 modified "2023-10-18" @default.
- W3010629691 title "Antiplasmodial Activities of Flavonoids from Leaves of <i>Securidaca longepedunculata</i> Fresen (Polygalaceae)" @default.
- W3010629691 doi "https://doi.org/10.11648/j.ajbio.20200801.11" @default.
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