FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010637897> ?p ?o ?g. }

• W3010637897 endingPage "116696" @default.
• W3010637897 startingPage "116696" @default.
• W3010637897 abstract "MRI studies show that obese adults have reduced grey matter (GM) and white matter (WM) tissue density as well as altered WM integrity. Bariatric surgery can lead to substantial weight loss and improvements in metabolic parameters, but it remains to be examined if it induces structural brain changes. The aim of this study was to characterize GM and WM density changes measured with MRI in a longitudinal setting following sleeve gastrectomy, and to determine whether any changes are related to inflammation and cardiometabolic blood markers. 29 participants with obesity (age: 45.9 ​± ​7.8 years) scheduled to undergo sleeve gastrectomy were recruited. High-resolution T1-weighted anatomical images were acquired 1 month prior to as well as 4 and 12 months after surgery. GM and WM densities were quantified using voxel-based morphometry (VBM). Circulating lipid profile, glucose, insulin and inflammatory markers (interleukin-6, C-reactive protein and lipopolysaccharide-binding protein) were measured at each time point. A linear mixed effect model was used to compare brain changes before and after SG, controlling for age, sex, initial BMI and diabetic status. To assess the associations between changes in adiposity, metabolism and inflammation and changes in GM or WM density, the mean GM and WM densities were extracted across all the participants using atlas-derived regions of interest, and linear mixed-effect models were used. As expected, weight, BMI, waist circumference and neck circumference significantly decreased after SG compared with baseline (p ​< ​0.001 for all). A widespread increase in WM density was observed after surgery, particularly in the cerebellum, brain stem, cerebellar peduncle, cingulum, corpus callosum and corona radiata (p ​< ​0.05, after FDR correction). Significant increases in GM density were observed 4 months after SG compared to baseline in several brain regions such as the bilateral occipital cortex, temporal cortex, postcentral gyrus, cerebellum, hippocampus and insula as well as right fusiform gyrus, right parahippocampal gyrus, right lingual gyrus and right amygdala. These GM and WM increases were more pronounced and widespread after 12 months and were significantly associated with post-operative weight loss and the improvement of metabolic alterations. A linear mixed-effect model also showed associations between post-operative reductions in lipopolysaccharide-binding protein, a marker of inflammation, and increased WM density. To confirm our results, we tested whether the peak of each significant region showed BMI-related differences in an independent dataset (Human Connectome Project). We matched a group of individuals who were severely obese with a group of individuals who were lean for age, sex and ethnicity. Severe obesity was associated with reduced WM density in the brain stem and cerebellar peduncle as well as reduced GM density in cerebellum, regions that significantly changed after surgery (p ​< ​0.01 for all clusters). Bariatric surgery-induced weight loss and improvement in metabolic alterations is associated with widespread increases in WM and GM densities. These post-operative changes overlapped with baseline brain differences between participants who were severely obese and those who were normal-weight in a separate dataset, which may suggest a recovery of WM and GM alterations after bariatric surgery." @default.
• W3010637897 created "2020-03-13" @default.
• W3010637897 creator A5021783699 @default.
• W3010637897 creator A5030230166 @default.
• W3010637897 creator A5032677599 @default.
• W3010637897 creator A5040001337 @default.
• W3010637897 creator A5040367799 @default.
• W3010637897 creator A5051732001 @default.
• W3010637897 creator A5051764425 @default.
• W3010637897 creator A5054295358 @default.
• W3010637897 creator A5061155266 @default.
• W3010637897 creator A5062358918 @default.
• W3010637897 creator A5071370188 @default.
• W3010637897 creator A5082932222 @default.
• W3010637897 creator A5087380570 @default.
• W3010637897 creator A5089022601 @default.
• W3010637897 date "2020-06-01" @default.
• W3010637897 modified "2023-09-25" @default.
• W3010637897 title "Neuroanatomical changes in white and grey matter after sleeve gastrectomy" @default.
• W3010637897 cites W1519538374 @default.
• W3010637897 cites W1704561002 @default.
• W3010637897 cites W1975829928 @default.
• W3010637897 cites W1983208069 @default.
• W3010637897 cites W1991334358 @default.
• W3010637897 cites W1998525855 @default.
• W3010637897 cites W2003539800 @default.
• W3010637897 cites W2004864469 @default.
• W3010637897 cites W2011790043 @default.
• W3010637897 cites W2020519533 @default.
• W3010637897 cites W2036245009 @default.
• W3010637897 cites W2045353197 @default.
• W3010637897 cites W2048589407 @default.
• W3010637897 cites W2058046532 @default.
• W3010637897 cites W2063430441 @default.
• W3010637897 cites W2065123450 @default.
• W3010637897 cites W2073081893 @default.
• W3010637897 cites W2079670970 @default.
• W3010637897 cites W2102264538 @default.
• W3010637897 cites W2105725047 @default.
• W3010637897 cites W2107363375 @default.
• W3010637897 cites W2125239733 @default.
• W3010637897 cites W2129082205 @default.
• W3010637897 cites W2133194839 @default.
• W3010637897 cites W2138399636 @default.
• W3010637897 cites W2139761769 @default.
• W3010637897 cites W2141796362 @default.
• W3010637897 cites W2142254202 @default.
• W3010637897 cites W2142592339 @default.
• W3010637897 cites W2148824609 @default.
• W3010637897 cites W2157848968 @default.
• W3010637897 cites W2159213084 @default.
• W3010637897 cites W2160234571 @default.
• W3010637897 cites W2199402593 @default.
• W3010637897 cites W2234399588 @default.
• W3010637897 cites W2279466966 @default.
• W3010637897 cites W2308899752 @default.
• W3010637897 cites W2406406058 @default.
• W3010637897 cites W2482381291 @default.
• W3010637897 cites W2485551923 @default.
• W3010637897 cites W2490128783 @default.
• W3010637897 cites W2528511584 @default.
• W3010637897 cites W2551228758 @default.
• W3010637897 cites W2560010162 @default.
• W3010637897 cites W2577163439 @default.
• W3010637897 cites W2583459617 @default.
• W3010637897 cites W2585202790 @default.
• W3010637897 cites W2596301176 @default.
• W3010637897 cites W2608727369 @default.
• W3010637897 cites W2636656601 @default.
• W3010637897 cites W2692655360 @default.
• W3010637897 cites W2732464357 @default.
• W3010637897 cites W2747197555 @default.
• W3010637897 cites W2751178109 @default.
• W3010637897 cites W2765345971 @default.
• W3010637897 cites W2766927536 @default.
• W3010637897 cites W2768962507 @default.
• W3010637897 cites W2788114851 @default.
• W3010637897 cites W2793260524 @default.
• W3010637897 cites W2803837136 @default.
• W3010637897 cites W2883300473 @default.
• W3010637897 cites W2903609187 @default.
• W3010637897 cites W2905428402 @default.
• W3010637897 cites W2952051960 @default.
• W3010637897 cites W2970186738 @default.
• W3010637897 cites W2993626059 @default.
• W3010637897 cites W4238608606 @default.
• W3010637897 doi "https://doi.org/10.1016/j.neuroimage.2020.116696" @default.
• W3010637897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32145436" @default.
• W3010637897 hasPublicationYear "2020" @default.
• W3010637897 type Work @default.
• W3010637897 sameAs 3010637897 @default.
• W3010637897 citedByCount "19" @default.
• W3010637897 countsByYear W30106378972021 @default.
• W3010637897 countsByYear W30106378972022 @default.
• W3010637897 countsByYear W30106378972023 @default.
• W3010637897 crossrefType "journal-article" @default.
• W3010637897 hasAuthorship W3010637897A5021783699 @default.
• W3010637897 hasAuthorship W3010637897A5030230166 @default.

• next