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• W3010656285 abstract "Abstract Purpose Rituximab is widely prescribed to treat systemic sclerosis (SSc) by the depletion of pathogenic B cells. Nonetheless, the clinical benefit of Rituximab in SSc remains contentious. This meta-analysis was conducted to systematically evaluate the safety and efficacy profile of Rituximab in SSc patients. Patients and methods We performed a systematic online query in PubMed, Cochrane, and Web of Science. The available studies on the use of Rituximab in SSc patients were comprehensively reviewed and investigated. Results In total, 14 studies, including 597 participants, were analyzed. Pooled results showed the long-term improvement in the modified Rodnan skin score (mRSS) for skin function (ΔmRSS: 7.00 at 6 months, 9.70 at 12 months, and 10.93 at 24 months), while forced vital capacity (FVC) (ΔFVC: −0.69 at 6 months, −2.62 at 12 months, and −0.67 at 24 months) and diffusing capacity of the lungs for carbon monoxide (DLCO) (ΔDLCO: −2.39 at 6 months, −3.28 at 12 months, and −0.79 at 24 months) for lung function remained stable in SSc patients after Rituximab treatment. The rate of Rituximab-related adverse events was 12% in the pooled results. Conclusion The pooled results of this meta-analysis indicated that Rituximab is well tolerated, and it is able to improve cutaneous function and stabilize pulmonary function in SSc patients." @default.
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• W3010656285 date "2020-06-01" @default.
• W3010656285 modified "2023-10-18" @default.
• W3010656285 title "Safety and efficacy of Rituximab in systemic sclerosis: A systematic review and meta-analysis" @default.
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• W3010656285 doi "https://doi.org/10.1016/j.intimp.2020.106389" @default.
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