Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010674612> ?p ?o ?g. }
- W3010674612 endingPage "48" @default.
- W3010674612 startingPage "48" @default.
- W3010674612 abstract "Infectious diseases in early postnatal ontogenesis often result in cognitive impairments, particularly learning and memory. The essential foundation of learning and memory is long-term synaptic plasticity, which depends on N-methyl-D-aspartate (NMDA) receptors. In the present study, bacterial infection was modeled by treating rat pups with bacterial lipopolysaccharide (LPS, 25 µg/kg) three times, during either the first or the third week of life. These time points are critical for the maturation of NMDA receptors. We assessed the effects of LPS treatments on the properties of long-term potentiation (LTP) in the CA1 hippocampus of young (21–23 days) and adolescent (51–55 days) rats. LTP magnitude was found to be significantly reduced in both groups of young rats, which also exhibited investigative and motor behavior disturbances in the open field test. No changes were observed in the main characteristics of synaptic transmission, although the LTP induction mechanism was disturbed. In rats treated with LPS during the third week, the NMDA-dependent form of LTP was completely suppressed, and LTP switched to the Type 1 metabotropic glutamate receptor (mGluR1)-dependent form. These impairments of synaptic plasticity and behavior were temporary. In adolescent rats, no difference was observed in LTP properties between the control and experimental groups. Lastly, the investigative and motor behavior parameters in both groups of adult rats were similar." @default.
- W3010674612 created "2020-03-23" @default.
- W3010674612 creator A5034201103 @default.
- W3010674612 creator A5054294231 @default.
- W3010674612 creator A5063372064 @default.
- W3010674612 creator A5068257435 @default.
- W3010674612 creator A5071594627 @default.
- W3010674612 date "2020-03-18" @default.
- W3010674612 modified "2023-09-27" @default.
- W3010674612 title "Administration of Bacterial Lipopolysaccharide during Early Postnatal Ontogenesis Induces Transient Impairment of Long-Term Synaptic Plasticity Associated with Behavioral Abnormalities in Young Rats" @default.
- W3010674612 cites W1488634403 @default.
- W3010674612 cites W1498951458 @default.
- W3010674612 cites W1542136448 @default.
- W3010674612 cites W1543895408 @default.
- W3010674612 cites W1576462562 @default.
- W3010674612 cites W1775494655 @default.
- W3010674612 cites W1908141284 @default.
- W3010674612 cites W1963735148 @default.
- W3010674612 cites W1966844341 @default.
- W3010674612 cites W1967912747 @default.
- W3010674612 cites W1970542265 @default.
- W3010674612 cites W1973372962 @default.
- W3010674612 cites W1992349983 @default.
- W3010674612 cites W1993028524 @default.
- W3010674612 cites W1993741388 @default.
- W3010674612 cites W1998636915 @default.
- W3010674612 cites W1999745140 @default.
- W3010674612 cites W1999970418 @default.
- W3010674612 cites W2002734542 @default.
- W3010674612 cites W2012865678 @default.
- W3010674612 cites W2019016101 @default.
- W3010674612 cites W2024380057 @default.
- W3010674612 cites W2027914644 @default.
- W3010674612 cites W2028594041 @default.
- W3010674612 cites W2028638764 @default.
- W3010674612 cites W2030382492 @default.
- W3010674612 cites W2037210922 @default.
- W3010674612 cites W2037852973 @default.
- W3010674612 cites W2038211748 @default.
- W3010674612 cites W2041351978 @default.
- W3010674612 cites W2044818530 @default.
- W3010674612 cites W2045700729 @default.
- W3010674612 cites W2049511526 @default.
- W3010674612 cites W2050066016 @default.
- W3010674612 cites W2052783666 @default.
- W3010674612 cites W2055151958 @default.
- W3010674612 cites W2056200351 @default.
- W3010674612 cites W2061096180 @default.
- W3010674612 cites W2061212294 @default.
- W3010674612 cites W2064639670 @default.
- W3010674612 cites W2065169750 @default.
- W3010674612 cites W2080341840 @default.
- W3010674612 cites W2082791664 @default.
- W3010674612 cites W2083048709 @default.
- W3010674612 cites W2085571457 @default.
- W3010674612 cites W2091855875 @default.
- W3010674612 cites W2102786824 @default.
- W3010674612 cites W2108089395 @default.
- W3010674612 cites W2109991966 @default.
- W3010674612 cites W2112927743 @default.
- W3010674612 cites W2116635659 @default.
- W3010674612 cites W2133285534 @default.
- W3010674612 cites W2141114982 @default.
- W3010674612 cites W2141998004 @default.
- W3010674612 cites W2161998020 @default.
- W3010674612 cites W2167916157 @default.
- W3010674612 cites W2171785899 @default.
- W3010674612 cites W2252829763 @default.
- W3010674612 cites W2330756578 @default.
- W3010674612 cites W2332732127 @default.
- W3010674612 cites W2567444348 @default.
- W3010674612 cites W2593612247 @default.
- W3010674612 cites W2604542316 @default.
- W3010674612 cites W2606822174 @default.
- W3010674612 cites W2750775516 @default.
- W3010674612 cites W2769803536 @default.
- W3010674612 cites W2804427175 @default.
- W3010674612 cites W2898344414 @default.
- W3010674612 cites W2906238344 @default.
- W3010674612 cites W2907593459 @default.
- W3010674612 cites W2955482511 @default.
- W3010674612 cites W2966787237 @default.
- W3010674612 cites W2969751900 @default.
- W3010674612 cites W4293029111 @default.
- W3010674612 doi "https://doi.org/10.3390/ph13030048" @default.
- W3010674612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7151710" @default.
- W3010674612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32197321" @default.
- W3010674612 hasPublicationYear "2020" @default.
- W3010674612 type Work @default.
- W3010674612 sameAs 3010674612 @default.
- W3010674612 citedByCount "7" @default.
- W3010674612 countsByYear W30106746122020 @default.
- W3010674612 countsByYear W30106746122021 @default.
- W3010674612 countsByYear W30106746122022 @default.
- W3010674612 countsByYear W30106746122023 @default.
- W3010674612 crossrefType "journal-article" @default.
- W3010674612 hasAuthorship W3010674612A5034201103 @default.
- W3010674612 hasAuthorship W3010674612A5054294231 @default.